Method and apparatus for controlling the focal point of a fixed beam focused on a sample in a rotating cell placed in a rotating disk

Abstract

a method and apparatus for controlling the position of a target point on a process result (10) relative to a focal point of a focus sensor system (20) to determine a characteristic of a process result (10) located within a cartridge (35), and wherein the focus sensor system (20) is fixed at a set position relative to a disk (40), the disk (40) being rotatable about a first axis (45) by a first motor connected to the controller, and wherein , the cartridge (35) is rotatable about a second axis (50) by a second motor connected to the controller, and wherein the cartridge (35) is smaller than the disc (40) and is placed in the disc (40) and offset from the center of the disc (40). The method comprises the steps of: determining a point within the box (35) as the initial focus point (55) of the focus sensor system (20); controlling the rotation of the box (35) and disc (40) so that the focus sensor system (20) The focus point corresponds to the initial focus point (55); check whether the initial focus point (55) of the focus sensor system (20) corresponds to the target point on the processing result (10) and adjust the box (35) and disc (40 ) so that the focus point of the focus sensor system (20) corresponds to a target point on the processing result (10), and checking the signal received from the focus sensor system (20) to determine the characteristics of the processing result (10) at the target point . The apparatus comprises means for performing the method.

Description

technical field [0001] The present invention relates to the field of centrifugation devices for processing samples in cartridges, and more particularly to methods and devices for measuring systems for controlling a focus point on and analyzing processing results in a cartridge. Background technique [0002] Centrifugal devices for processing samples in cartridges by centrifugation are well known and are an integral part of chemical and biochemical science protocols. Processing is performed by accelerating the sample to perform sedimentation of cells, particles and sediments and separation of liquids or cells with different densities. [0003] Biaxial centrifugation is usually obtained in an apparatus that performs rotation of the cartridge about the axis of the cartridge while the cartridge is rotated about the distal axis by a separate device. [0004] An example of such a system is described in WO 2011 / 081531 A1 (Borch et al.), where a dual axis centrifugation device for ...

AI Technical Summary

Problems solved by technology

Even if the target point on the process result is defined and the rotation of the disc is controlled accordingly, the actual target point may vary from one cassette to another due to different factors such as different manufacturing tolerances of the cassettes, different temperatures, etc. slightly different

Images