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A kind of phase-change nano-diagnosis and treatment agent composite material, preparation method and application thereof

A technology of composite materials and phase change materials, applied in the fields of wave energy or particle radiation treatment materials, pharmaceutical formulations, drug combinations, etc. The size and shape of the product and the problems of insufficient biosafety can achieve the effect of overcoming long-term retention in the body, improving biosafety, and increasing water solubility.

Active Publication Date: 2022-03-22
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the disadvantages of this patented technology are: 1. The preparation process of hollow mesoporous Prussian blue nanoparticles is time-consuming, and the prepared nanoparticles have a particle size of 100nm-500nm, which cannot be effectively used in vivo; 2. This patent introduces Prussian blue as a dye, so the prepared nanoparticles are less stable to light, and the storage conditions have certain restrictions; 3. In the sixth embodiment of this patent, high power density (5W / cm 2 ) to measure the photothermal conversion characteristics, which cannot explain the excellent photothermal conversion characteristics of the prepared Prussian blue nanoparticles; 2 and 2W / cm 2 Power density, high power density, indicating that the biological safety of the material is not high enough
Since the soft template method has the advantages of simple method, convenient operation, and low cost, the application is gradually increasing, but because the soft film plate cannot strictly control the size and shape of the product, its application has been limited.

Method used

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  • A kind of phase-change nano-diagnosis and treatment agent composite material, preparation method and application thereof
  • A kind of phase-change nano-diagnosis and treatment agent composite material, preparation method and application thereof
  • A kind of phase-change nano-diagnosis and treatment agent composite material, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0048] The phase-change nano-diagnosis and treatment agent composite material provided by the embodiment of the present invention is based on mesoporous carbon nanoparticles MCNs with mesoporous surfaces and an ordered pore structure inside, and mesoporous carbon nanoparticles OMCNs obtained by oxidative modification as a carrier , the composite material OMCNs-PFP obtained by loading temperature-sensitive phase change materials in the particle pore structure, and its mesopore shape difference is small, the particle shape size is uniform, it has good water solubility, biocompatibility, and has Properties of the photothermal effect and photoacoustic / ultrasound imaging.

[0049] In the dry matter of the finished product of the composite material OMCNs-PFP, the mass fraction of the mesoporous carbon nanoparticles OMCNs is 95%-97.0%, and the mass fraction of the temperature-sensitive phase change material PFP is 3.0%-5%; The temperature-sensitive phase change material PFP is perflu...

Embodiment 2

[0070] The mesoporous carbon-based phase-change nano-diagnostic agent composite material, preparation method and application provided in this embodiment are basically the same as in Example 1, except that:

[0071] In the dry matter of the finished product of the composite material OMCNs-PFP, the mass fraction of the mesoporous carbon nanoparticle OMCNs is 95.5%, and the mass fraction of the temperature-sensitive phase change material PFP is 4.5%.

[0072] The preparation method of the phase-change nano-diagnostic agent composite material based on mesoporous carbon provided in this embodiment comprises the following steps:

[0073] (1) Dissolve 0.98g of F127 in 15mL of deionized water using the "soft template" method; accurately weigh 0.65g of phenol, 2.1mL of formaldehyde, and 15mL of 0.1mol L -1 Mix NaOH evenly at 70°C at 340r·min -1 Stir at a constant speed for 30 minutes at a rotating speed to synthesize a low molecular weight phenolic resin; then pour the dissolved F127 ...

Embodiment 3

[0096] The mesoporous carbon-based phase-change nano-diagnostic agent composite material, preparation method and application provided in this embodiment are basically the same as those in Examples 1 and 2, except that:

[0097] In the dry matter of the finished product of the composite material OMCNs-PFP, the mass fraction of the mesoporous carbon nanoparticle OMCNs is 96%, and the mass fraction of the temperature-sensitive phase change material PFP is 4%.

[0098] Specifically, the prepared phase-change nano-diagnostic agent composite material is used as a material for preparing photothermal reagents for near-infrared photothermal therapy, and then applied to photothermal experiments, including the following steps:

[0099] (1) Using ultrapure water to prepare the phase-change nano-diagnostic agent composite materials with nanoparticle concentrations of 50 μg / mL, 100 μg / mL, 150 μg / mL, and 200 μg / mL, respectively;

[0100] (2) Take 1mL each in a cuvette and use an 808nm laser ...

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Abstract

The invention relates to the technical field of medical bio-nano materials, and discloses a phase-change nano-diagnosis and treatment agent composite material, which is characterized in that it is mesoporous carbon nanoparticle MCNs with mesoporous surface and ordered pore structure inside. The modified mesoporous carbon nanoparticle OMCNs is used as a carrier, and the composite material OMCNs‑PFP is obtained by loading temperature-sensitive phase change materials in the particle channel structure, and its mesoporous shape difference is small, and the particle shape and size are uniform. Good water solubility, biocompatibility, and properties of photothermal effect and photoacoustic / ultrasonic imaging. The invention also discloses a preparation method and application of the composite material. The invention can realize the nanoscale structure of the composite material, and the composite material has good stability, uniformity, biocompatibility, high biological safety, and is easy for mass production and industrialization.

Description

technical field [0001] The invention relates to the technical field of medical biological nanomaterials, in particular to a mesoporous carbon-based phase-change nano-diagnosis and treatment agent composite material, a preparation method and its application in tumor photothermal therapy and multi-mode imaging diagnosis. Background technique [0002] Under the long-term influence of carcinogenic factors, certain tissues of the body will undergo lesions, which are mostly caused by mutations at the gene level. We call such lesions, abnormal body tissues tumors, and malignant tumors We call it cancer. Today, with the continuous development of the medical level, cancer is still a major threat to human life and health all over the world, and the treatment of cancer is also a major issue and problem in medicine that needs to be overcome urgently. Nanotechnology has developed rapidly in recent years and can be applied in multidisciplinary and comprehensive research fields. In the e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22A61K41/00A61P35/00
CPCA61K49/225A61K41/0052A61P35/00
Inventor 刘金亮张勇李勇张菁
Owner SHANGHAI UNIV
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