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Application of tert-butyl hydroquinone and drug for treating intervertebral disc degeneration

A technology of tertiary butyl hydroquinone and intervertebral disc, which is applied in the field of medicine to achieve good anti-oxidation effect and alleviate the effect of intervertebral disc degeneration

Inactive Publication Date: 2020-08-14
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been reported that tertiary butyl hydroquinone can be used to effectively treat or delay intervertebral disc degeneration

Method used

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  • Application of tert-butyl hydroquinone and drug for treating intervertebral disc degeneration
  • Application of tert-butyl hydroquinone and drug for treating intervertebral disc degeneration
  • Application of tert-butyl hydroquinone and drug for treating intervertebral disc degeneration

Examples

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Embodiment 1

[0027] This embodiment provides a drug for treating intervertebral disc degeneration, which can be used for treating or delaying intervertebral disc degeneration. Specifically, the drug includes a drug carrier and tert-butyl hydroquinone; wherein, the drug carrier is a commercially available ethyl oleate microemulsion, and each g of the drug contains 0.2 g of tert-butyl hydroquinone. It should be noted that the preparation method of the drug does not belong to the improvement point of the present invention, and it can be prepared by existing common pharmaceutical processes, so it will not be described in detail here.

Embodiment 2

[0029] This embodiment provides a drug for treating intervertebral disc degeneration, which can be used for treating or delaying intervertebral disc degeneration. Specifically, the medicine includes a drug carrier and tertiary butyl hydroquinone; wherein, the drug carrier is a commercially available ethyl oleate microemulsion, and each g of the drug contains 0.3 g of tertiary butyl hydroquinone. It should be noted that the preparation method of the drug does not belong to the improvement point of the present invention, and it can be prepared by existing common pharmaceutical processes, so it will not be described in detail here.

Embodiment 3

[0031] This embodiment provides a drug for treating intervertebral disc degeneration, which can be used for treating or delaying intervertebral disc degeneration. Specifically, the drug includes a drug carrier and tert-butyl hydroquinone; wherein, the drug carrier is a commercially available ethyl oleate microemulsion, and each g of the drug contains 0.251 g of tert-butyl hydroquinone. It should be noted that the preparation method of the drug does not belong to the improvement point of the present invention, and it can be prepared by existing common pharmaceutical processes, so it will not be described in detail here.

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Abstract

The invention is applicable to the technical field of medicines, and provides an application of tert-butyl hydroquinone and a drug for treating intervertebral disc degeneration. The drug for treatingintervertebral disc degeneration comprises a drug carrier and tert-butyl hydroquinone, wherein the tert-butyl hydroquinone is a safe and efficient edible oil antioxidant and has a good antioxidant effect. Compared with other drugs, the tert-butyl hydroquinone serving as a food additive component can relieve intervertebral disc degeneration more mildly. The tert-butyl hydroperoxide is applied to induce oxidative stress to construct an intervertebral disc degeneration model, the treatment effect of the tert-butyl hydroquinone on intervertebral disc degeneration is evaluated by observing variousindexes of oxidative stress, cell apoptosis and intervertebral disc degeneration, and a substitute treatment drug can be provided for comprehensive treatment of intervertebral disc degeneration diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an application of tertiary butyl hydroquinone and a medicine for treating intervertebral disc degeneration. Background technique [0002] Intervertebral Disc (IVD) degeneration is a spinal degenerative disease caused by various factors such as immunology, molecular biology and biomechanics. With the arrival of an aging society, the prevalence of degenerative disc diseases is increasing. Severe spinal cord and neuropathy may occur in the later stage of the patient, seriously affecting the quality of life of the patient and causing a huge social burden. There is no clinically effective drug for the treatment of intervertebral disc degeneration. [0003] The etiology of intervertebral disc degeneration is diverse, such as abnormal biological stress, inflammatory response, natural aging, nutritional deficiency, and abnormally increased oxidative stress. Among them, ox...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K9/127A61K9/107A61K45/06A61P19/00B82Y5/00A61P19/08A61K31/56A61K31/436A61K31/155A61K31/4045
CPCA61K9/1075A61K9/127A61K31/05A61K31/155A61K31/4045A61K31/436A61K31/56A61K45/06A61P19/00A61P19/08B82Y5/00A61K2300/00
Inventor 胡孙理王向阳
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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