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Drug-loading microacupuncture needle, drug-loading microacupuncture needle paster, microacupuncture needle system for electrically adjusting and controlling drug release, and preparation method of drug-loading microacupuncture needle

An electrical regulation and microneedle technology, applied in microneedles, pharmaceutical formulations, drug delivery, etc., can solve the problems of easy shedding of the coating, complicated preparation, and difficult to control the size of the microneedle, so as to solve the easy shedding of the coating and ensure the drug delivery effect. Effect

Pending Publication Date: 2020-09-11
赵超超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The main purpose of the embodiments of the present invention is to provide a drug-loaded microneedle, a drug-loaded microneedle patch, an electrically regulated drug release microneedle system, and a method for preparing a drug-loaded microneedle (a drug-loaded microneedle, drug-loaded microneedle preparation method, a device using a drug-loaded microneedle, a drug-loaded microneedle, a device using the same, and a preparation method thereof) to solve problems in the prior art that the coating layer of the coated microneedle is easy to fall off, the controllability of drug release is not ideal, At least one of the technical problems of complex preparation, difficult control of microneedle size, and poor skin fit

Method used

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  • Drug-loading microacupuncture needle, drug-loading microacupuncture needle paster, microacupuncture needle system for electrically adjusting and controlling drug release, and preparation method of drug-loading microacupuncture needle
  • Drug-loading microacupuncture needle, drug-loading microacupuncture needle paster, microacupuncture needle system for electrically adjusting and controlling drug release, and preparation method of drug-loading microacupuncture needle
  • Drug-loading microacupuncture needle, drug-loading microacupuncture needle paster, microacupuncture needle system for electrically adjusting and controlling drug release, and preparation method of drug-loading microacupuncture needle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The embodiment of the present application provides a drug-loaded microneedle 100. The drug-loaded microneedle 100 is applied to an electrically regulated drug release microneedle system 300. The electrically regulated drug release microneedle system 300 has a function for providing electric energy and controlling the electronically regulated drug release. The driving power device 301 for the microneedle system 300 to release the drug.

[0056] figure 1 is a schematic diagram of the structure of drug-loaded microneedles according to some embodiments. Figure 4 is a schematic structural view of an electrically regulated drug release microneedle system according to some embodiments.

[0057] Please refer to figure 1 and Figure 4 The drug-loaded microneedle 100 includes a microneedle base 10, at least one microneedle body 20, a conductive polymer nano-doped body 30, and a microneedle drug.

[0058] The microneedle base 10 is mainly used to support several microneedle b...

Embodiment 2

[0086] image 3 is a schematic structural view of a drug-loaded microneedle patch according to some embodiments.

[0087] Please refer to image 3 , this embodiment provides a drug-loaded microneedle patch 200, the drug-loaded microneedle 100 is applied to an electrically regulated drug release microneedle system 300, and the electrically regulated drug release microneedle system 300 has a function for providing electrical energy and controlling the electrical The drug-releasing microneedle system 300 is a drive power device 301 for releasing drugs, and the drug-loaded microneedle patch 200 includes a substrate 201 and at least one drug-loaded microneedle according to any embodiment of the above-mentioned Example 1.

[0088] The substrate 201 mainly supports and / or fixes the drug-loaded microneedle 100 . The substrate 201 may be a flexible material. The substrate 201 can also be an adhesive material, which is convenient for fixing the drug-loaded microneedle 100 on the skin...

Embodiment 3

[0092] Figure 4 is a schematic structural view of an electrically regulated drug release microneedle system according to some embodiments. Figure 7 is a schematic diagram of the functional modules of the electronically regulated drug release microneedle system according to some embodiments.

[0093] Please refer to Figure 4 and Figure 7 , the embodiment of the present application provides an electrically regulated drug release microneedle system 300, the electrically regulated drug release microneedle system 300 includes a driving power supply device 301, the drug-loaded microneedle 100 in any embodiment of the above-mentioned embodiment 1 or the above-mentioned embodiment Drug-loaded microneedle patch 200 in Example 2.

[0094] The driving power supply device 301 is configured to provide electric energy to the drug-loaded microneedles 100 of any embodiment in the above-mentioned embodiment 1 or the drug-loaded microneedles 100 of the drug-loaded microneedle patch 200 i...

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Abstract

The invention discloses a drug-loading microacupuncture needle, a drug-loading microacupuncture needle paster, a microacupuncture needle system for electrically adjusting and controlling drug release,and a preparation method of the drug-loading microacupuncture needle, and belongs to the technical field of releasing of drugs loaded by a microacupuncture needle. The drug-loading microacupuncture needle comprises a microacupuncture needle base, one or more microacupuncture needle bodies formed on the microacupuncture needle base, conductive polymer nanometer doping bodies doped in the microacupuncture needle bodies and microacupuncture needle drugs doped in the conductive polymer nanometer doping bodies, wherein the microacupuncture needle bodies are used for puncturing the skin to transport the conductive polymer nanometer doping bodies into the skin; and the conductive polymer nanometer doping bodies are configured to respond to electric stimulation sent by a driving power source device to release the microacupuncture needle drugs. Through the adoption of the drug-loading microacupuncture needle disclosed by the invention, a plurality of technical problems that in the prior art, coating in a coating microacupuncture needle is easy to come off, the coating microacupuncture needle is not ideal in drug release controllability, complex in preparation, difficult in control of the dimension of microacupuncture needles, poor in skin adhering performance and the like are synchronously solved.

Description

technical field [0001] The invention relates to the technical field of drug-loaded release from microneedles, in particular to a drug-loaded microneedle, a drug-loaded microneedle patch, an electrically regulated drug release microneedle system, and a method for preparing a drug-loaded microneedle. Background technique [0002] As a new type of transdermal drug delivery system, microneedles can pierce the stratum corneum of the skin during drug delivery, thereby opening a microchannel from the stratum corneum to the epidermis or superficial dermis for drug delivery, and then Capillary absorption, drug active molecules are accompanied by blood circulation, and reach the focus of the human body to play a therapeutic role. Compared with the traditional transdermal drug delivery system, since the microneedle does not touch the nerve endings in the dermis, the microneedle drug delivery system has the advantages of no pain, self-medication, accurate and fast drug delivery, and eas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/70A61K47/34A61M37/00
CPCA61K9/0021A61K9/7023A61K47/34A61M37/0015A61M2037/0023A61M2037/0053A61M2037/0061
Inventor 胥玲玲杨圆赵超超
Owner 赵超超
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