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Application of taurolidine in preparation of anti-coronavirus drugs

A coronavirus and taurolidine technology, applied in the field of medicine, can solve problems such as taurolidine being discovered by no one

Inactive Publication Date: 2020-09-15
CHANGCHUN MAILING BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far no one has found that taurolidine can be used for anti-coronavirus

Method used

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  • Application of taurolidine in preparation of anti-coronavirus drugs
  • Application of taurolidine in preparation of anti-coronavirus drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The inhibition experiment of embodiment 1 taurolidine to coronavirus HCoV-229E

[0016] 1. Experimental materials:

[0017] 1.1 cell human lung cancer cell A549, from the Virology Laboratory of the Military Veterinary Research Institute;

[0018] 1.2 The virus strain HCoV-229E comes from the Virology Laboratory of the Military Veterinary Research Institute;

[0019] 1.3 Reagent DMEM, 0.25% trypsin, FBS, PBS (FH=7.0);

[0020] 1.4 Instrument Consumables Pipette and supporting tips, 1.5mL centrifuge tube, ice box, ice maker, biological safety cabinet, carbon dioxide incubator.

[0021] 2. Experimental method:

[0022] 2.1 Cell culture The human lung cancer cell A549 was resuscitated, continuously passed on for three generations, and used for experimental research after the cells grew well;

[0023] 2.2 Virus culture Put the preserved virus solution on ice to slowly thaw and inoculate it on a single layer of human lung cancer cells A549 (not exceeding 24 hours), contin...

Embodiment 2

[0031] The inhibitory experiment of embodiment 2 taurolidine to coronavirus SARS-CoV

[0032] 1. Experimental materials:

[0033] 1.1 Cell 293T cells, from the Virology Laboratory of the Military Veterinary Research Institute;

[0034] 1.2 The virus strain SARS-CoV comes from the Virology Laboratory of the Military Veterinary Research Institute;

[0035] 1.3 Reagent DMEM, 0.25% trypsin, FBS, PBS (FH=7.0);

[0036] 1.4 Instrument Consumables Pipette and supporting tips, 1.5mL centrifuge tube, ice box, ice maker, biological safety cabinet, carbon dioxide incubator.

[0037] 2. Experimental method:

[0038] 2.1 Cell culture The 293T cells were revived and passed on for three consecutive generations, and used for experimental research after the cells grew well;

[0039] 2.2 Virus culture Place the preserved virus liquid on ice to slowly thaw, inoculate it on a monolayer of 293T cells (not exceeding 24 hours), continue to culture for 72-96 hours, and harvest the virus liquid ac...

Embodiment 3

[0047] Embodiment 3 taurolidine is to the inhibition experiment of coronavirus MERS-CoV

[0048] 1. Experimental materials:

[0049]1.1 Cell 293T cells, from the Virology Laboratory of the Military Veterinary Research Institute;

[0050] 1.2 The strain of MERS-CoV comes from the Virology Laboratory of the Military Veterinary Research Institute;

[0051] 1.3 Reagent DMEM, 0.25% trypsin, FBS, PBS (FH=7.0);

[0052] 1.4 Instrument Consumables Pipette and supporting tips, 1.5mL centrifuge tube, ice box, ice maker, biological safety cabinet, carbon dioxide incubator.

[0053] 2. Experimental method:

[0054] 2.1 Cell culture The 293T cells were revived and passed on for three consecutive generations, and used for experimental research after the cells grew well;

[0055] 2.2 Virus culture Put the preserved virus liquid on ice to slowly melt, inoculate it on a monolayer of 293T cells (not exceeding 24 hours), continue to culture for 72-96 hours, and harvest the virus liquid accor...

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Abstract

The invention discloses application of taurolidine in preparation of anti-coronavirus drugs, and relates to the technical field of medicines. The new application of taurolidine is discovered for the first time, namely the application of taurolidine in inhibition of coronavirus or in preparation of anti-coronavirus drugs, and coronavirus is HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HCoV-HKU1 or MERS-CoV. The safety of taurolidine to a human body is detected through clinical practice, the obvious drug effect of taurolidine to coronavirus is found, a powerful theoretical basis and a practical basis are provided for coronavirus resistance, and the taurolidine has development value and popularization significance. The invention provides a new way for treating diseases caused by coronavirus infection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an application of taurolidine in the preparation of anti-coronavirus drugs. Background technique [0002] Coronavirus is an RNA virus with an envelope and a linear single-stranded positive strand genome. It is a large class of viruses that exist widely in nature. The diameter of coronavirus is about 80-120nm, the 5′ end of the genome has a methylated cap structure, and the 3′ end has a poly(A) tail. The total length of the genome is about 27-32kb. . Coronaviruses can be widespread in humans and other mammals, as well as birds, and cause respiratory, digestive, hepatic, and neurological diseases, among other types. However, there is currently no approved specific drug to treat infections caused by coronaviruses. Even for patients with severe acute respiratory tract infection caused by SARS-CoV and MERS-CoV, symptomatic treatment is mainly used to reduce complications in patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61P31/14
CPCA61K31/549A61P31/14
Inventor 苏熙尧李维城赵喜伍轩辕浩宇卢伟陈强严庆文苏忠
Owner CHANGCHUN MAILING BIOLOGICAL ENG CO LTD
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