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Agriophyllum squarrosum extract as well as extraction method and application thereof

An extraction method and extract technology, which are applied in the directions of pharmaceutical formulations, drug combinations, plant raw materials, etc., can solve the problem of myocardial damage without good specific drugs, etc., and achieve the effect of improving myocardial damage.

Active Publication Date: 2020-10-13
包书茵
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] In order to solve the above problems and overcome the deficiencies in the prior art, the present invention provides a saponin extract, an extraction method and its application, which can effectively solve the myocardial injury induced by various pathologies of isoprenaline, which has not been well solved. The problem with specific drugs

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  • Agriophyllum squarrosum extract as well as extraction method and application thereof
  • Agriophyllum squarrosum extract as well as extraction method and application thereof
  • Agriophyllum squarrosum extract as well as extraction method and application thereof

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specific Embodiment approach

[0033] The main process conditions for the extract of A. arborescens: crushing and extracting ethanol backflow, filtering the extract, combining the filtrates to recover ethanol under reduced pressure, diluting with an equal volume of water, filtering, and passing the filtrate through an adsorption resin column, eluting with water, and collecting The water eluate was concentrated under reduced pressure.

[0034] The above-mentioned process can be further optimized: take sarcophagus, crush it into the coarsest powder, add 10, 8 times the amount of 95% ethanol to reflux and extract twice, each time for 2 hours, combine the extracts, and discard the residue; add 10, 8 times of the degreasing powder in turn, 8, 8 times the amount of 70% ethanol reflux extraction 3 times, 2 hours for the first time, 1 hour for the second and third times, filter the extract, combine the filtrate to recover ethanol under reduced pressure, concentrate to no alcohol smell (1g: 1ml ), then diluted with ...

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Abstract

The invention discloses an agriophyllum squarrosum extract as well as an extraction method and an application thereof, and is characterized in that the agriophyllum squarrosum extract is used for protecting heart injury, particularly isoproterenol-induced myocardial injury; the beneficial effects of the invention are as follows: agriophyllum squarrosum oligosaccharide can reduce myocardial ischemia by maintaining the integrity of myocardial cells, so as to achieve the effect of relieving acute myocardial damage induced by isoproterenol, and the agriophyllum squarrosum oligosaccharide can havea good effect on myocardial damage induced by various pathology mechanisms of isoproterenol and has a certain improvement effect on myocardial damage caused by various pathology mechanisms of isoproterenol. The extract has a certain protective effect on myocardial damage, and is a novel, efficient and low-toxicity medicine for preventing and treating isoproterenol-induced acute myocardial damage by virtue of a multi-target regulating effect.

Description

Technical field: [0001] The invention belongs to the technical field of natural medicines, and more specifically relates to a saponin extract, an extraction method and an application thereof. Background technique: [0002] Cardiovascular system disease is the most common type of human disease and has become the number one cause of death in the world today. Myocardial injury is a category of cardiovascular system diseases, and the proportion of cardiovascular system diseases is increasing. Myocardial injury is also the injury of myocardial cells, that is, the changes caused by myocardial cell inflammation, necrosis, and degeneration and edema. [0003] The cause of myocardial injury can be caused by coronary artery disease caused by severe ischemia, such as acute coronary syndrome, coronary heart disease, and acute myocardial infarction. It can also be myocardial injury caused by inflammation, such as myocarditis and pericarditis. [0004] Another category is the result of...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K31/702A61P9/00
CPCA61K36/185A61K31/702A61P9/00A61K2236/333A61K2236/55
Inventor 包书茵苏维恒奥·乌力吉王秀枝
Owner 包书茵
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