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Composition with anti-tumor active component as well as preparation method and application of composition

A technology of anti-tumor activity and composition, applied in the direction of inorganic active ingredients, anti-tumor drugs, and medical preparations of non-active ingredients, etc., which can solve the problems of human toxic side effects and single drug load

Pending Publication Date: 2020-10-20
德阳肿瘤医院有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an anti-tumor active ingredient composition and its preparation method and methods for the existing slow-release drug particles in the above-mentioned prior art, which have some toxic and side effects on the human body, and the drug load is relatively single. application

Method used

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  • Composition with anti-tumor active component as well as preparation method and application of composition
  • Composition with anti-tumor active component as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A preferred embodiment of the present invention provides a method for preparing an anti-tumor active ingredient composition, the specific steps are as follows:

[0041] S1. Gradually add the alloferon-1 peptide with a concentration of 0.1wt% into the cisplatin solution with a concentration of 0.05wt%, and filter and sterilize it through a 0.22 μm filter to obtain a drug mixture;

[0042] S2. Dissolving chitosan in a solution of 5vt% acetic acid, then adjusting the pH of the system to 5-6 with NaOH solution, and then dripping in a concentration of 1mg / mL sodium tripolyphosphate at a rate of 15-30mL / h solution, continue to stir for 24h, separate, wash and dry to obtain chitosan microspheres; wherein, the ratio of chitosan, acetic acid solution and sodium tripolyphosphate solution is 10mg: 6mL: 2mL;

[0043] S3. Disperse the chitosan microspheres obtained in S2 in water to make a concentration of 150g / L microsphere suspension, then add an equal volume of the drug mixture o...

Embodiment 2

[0047] A preferred embodiment of the present invention provides a method for preparing an anti-tumor active ingredient composition, the specific steps are as follows:

[0048] S1. Gradually add the alloferon-1 peptide with a concentration of 0.12wt% into the cisplatin solution with a concentration of 0.05wt%, and filter and sterilize it through a 0.22 μm filter to obtain a drug mixture;

[0049] S2. Chitosan is dissolved in the concentration of 6vt% acetic acid solution, then the pH value of the system is adjusted to 5-6 with NaOH solution, and then the concentration is 1mg / mL sodium tripolyphosphate is added dropwise at a speed of 15-30mL / h solution, continue to stir for 24h, separate, wash and dry to obtain chitosan microspheres; wherein, the ratio of chitosan, acetic acid solution and sodium tripolyphosphate solution is 10mg:5mL:3mL;

[0050] S3. Disperse the chitosan microspheres obtained in S2 in water to make a concentration of 150g / L microsphere suspension, then add an ...

Embodiment 3

[0054] A preferred embodiment of the present invention provides a method for preparing an anti-tumor active ingredient composition, the specific steps are as follows:

[0055] S1. Gradually add the alloferon-1 peptide with a concentration of 0.1wt% into the cisplatin solution with a concentration of 0.05wt%, and filter and sterilize it through a 0.22 μm filter to obtain a drug mixture;

[0056] S2. Dissolving chitosan in a solution of 5vt% acetic acid, then adjusting the pH of the system to 5-6 with NaOH solution, and then dripping in a concentration of 1mg / mL sodium tripolyphosphate at a rate of 15-30mL / h solution, continue to stir for 24h, separate, wash and dry to obtain chitosan microspheres; wherein, the ratio of chitosan, acetic acid solution and sodium tripolyphosphate solution is 8mg: 6mL: 2mL;

[0057] S3. Disperse the chitosan microspheres obtained in S2 in water to make a concentration of 150g / L microsphere suspension, then add an equal volume of the drug mixture ob...

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Abstract

The invention discloses a composition with an anti-tumor active component as well as a preparation method and application of the composition. The preparation method comprises the following steps: (S1)preparing a drug mixture; (S2) preparing chitosan microspheres; (S3) preparing drug-carrying chitosan microspheres A; (S4) preparing drug-carrying chitosan microspheres B; and (S5) adding IL-2 into achitosan dilute acid solution, carrying out continuous stirring at 10-30 DEG C, adding a sodium glycerophosphate solution, adding the drug-carrying chitosan microspheres A prepared in the step (S3) and the drug-carrying chitosan microspheres B prepared in the step (S4), and carrying out uniform mixing. By preparing the chitosan-gel-state composition containing drug-carrying microspheres, a pharmaceutical composition containing anti-tumor active factors is formed, is good in biocompatibility, has a good slow-release effect, has no toxic and side effects to normal tissues and further has a certain antibacterial property.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to an anti-tumor active ingredient composition and a preparation method and application thereof. Background technique [0002] At present, with the development of modern science and technology, people's living standards are also improving, but under the combined effect and influence of many factors such as environmental damage, air pollution, food safety, etc., people's physical health is declining day by day, and cancer patients are getting more and more Many, making cancer the number one cause of death in today's society, a serious threat to our lives. How to effectively suppress tumors has become the focus of attention. [0003] For patients with advanced cancer, they are generally weak in constitution, often lose indications for surgery, and cannot use strong radiotherapy and chemotherapy. The implantation of sustained-release drug particles has a high...

Claims

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Application Information

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IPC IPC(8): A61K38/20A61K47/36A61P35/00A61P31/04A61K33/243A61K31/65A61K38/10
CPCA61K38/2013A61K33/243A61K31/65A61K38/10A61K47/36A61P35/00A61P31/04A61K2300/00
Inventor 钟立松田博文曾德海曾令春袁亮黄婧王园园吴强邓田林
Owner 德阳肿瘤医院有限责任公司
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