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Compound, traditional Chinese medicine probiotic fermentation product, and application thereof in preparation of medicine or health care product with immunity enhancing effect

A technology of fermentation products and compounds, applied in the field of biomedicine, can solve problems such as enhancing immunity

Inactive Publication Date: 2020-10-20
刘志刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fast pace of modern society, most people cannot exercise every day to enhance immunity

Method used

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  • Compound, traditional Chinese medicine probiotic fermentation product, and application thereof in preparation of medicine or health care product with immunity enhancing effect
  • Compound, traditional Chinese medicine probiotic fermentation product, and application thereof in preparation of medicine or health care product with immunity enhancing effect
  • Compound, traditional Chinese medicine probiotic fermentation product, and application thereof in preparation of medicine or health care product with immunity enhancing effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The preparation of embodiment 1 formula (I) compound

[0057] (1) Take the raw material of traditional Chinese medicine and add 8 times of water to extract, soak for 50 minutes, and ultrasonically extract for 30 minutes; concentrate the extract to 1 / 3 volume to obtain a concentrated solution; then add fermented nutrients to the concentrated solution; then add probiotics at a temperature of Fermentation at 39°C and pH 7.0 for 48 hours to obtain a fermentation broth;

[0058] (2) centrifuging the fermentation broth at 8000r / min for 30min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a crude product;

[0059] (3) separating the crude product by chromatographic techniques to obtain the compound of formula (I);

[0060] The traditional Chinese medicine raw material described in the step (1) is composed of ginseng, wolfberry and jujube in a weight ratio of 2:1:1;

[0061] The add-on of fermented nutrient in step (1) is ...

Embodiment 2

[0067] The preparation of embodiment 2 traditional Chinese medicine probiotic fermentation product

[0068] (1) Take the raw material of traditional Chinese medicine and add 8 times of water to extract, soak for 50 minutes, and ultrasonically extract for 30 minutes; concentrate the extract to 1 / 3 volume to obtain a concentrated solution; then add fermented nutrients to the concentrated solution; then add probiotics at a temperature of Fermentation at 39°C and pH 7.0 for 48 hours to obtain a fermentation broth;

[0069] (2) centrifuging the fermented liquid at 8000r / min for 30 min, removing the precipitate and retaining the supernatant, and freeze-drying the supernatant to obtain a traditional Chinese medicine probiotic fermentation product;

[0070] The traditional Chinese medicine raw material described in the step (1) is composed of ginseng, wolfberry and jujube in a weight ratio of 2:1:1;

[0071] The add-on of fermented nutrient in step (1) is calculated according to the ...

experiment example 1

[0073] Experimental example 1 Effects of traditional Chinese medicine probiotic fermentation products and monomeric compounds of formula (I) on ConA-induced transformation of mouse spleen lymphocytes

[0074] (1) Experimental animals

[0075] Forty-eight female mice of SPF grade Kunming species were selected, aged 6-8 weeks (body weight 18-22 g), and raised in the feeding room of the Experimental Animal Center of Peking University (Shenzhen).

[0076] (2) Dose and grouping

[0077] The experiment is based on 5 times (0.25g / kg·BW), 10 times (0.5g / kg·BW) and 20 times ( 1.0g / kg·BW) were divided into control group and low-dose, middle-dose and high-dose groups, 12 rats in each group.

[0078] (3) Feeding method

[0079] During the experiment, 1.00 g of the fermentation product of traditional Chinese medicine probiotics and the monomeric compound sample with the structure of formula (I) were weighed, and 20 mL of sample liquid was prepared with purified water, which were used fo...

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Abstract

The invention relates to the technical field of biomedicine, and particularly discloses a compound, a traditional Chinese medicine probiotic fermentation product and application thereof in the preparation of a medicine or a health care product with an immunity enhancing effect. The traditional Chinese medicine probiotic fermentation product comprises a compound as shown in a formula (I). The preparation method comprises the following steps: (1) fermenting traditional Chinese medicine raw materials by probiotics to obtain fermentation broth; and (2) drying the fermentation broth to obtain the traditional Chinese medicine probiotic fermentation product, wherein the traditional Chinese medicine raw materials in the step (1) comprise ginseng, Chinese wolfberry and Chinese dates. The compound shown in the formula (I) and the traditional Chinese medicine probiotic fermentation product have the effect of enhancing immunity and can be used for preparing medicines and health care products.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a compound, a traditional Chinese medicine probiotic fermentation product and its application in the preparation of medicines or health care products capable of enhancing immunity. Background technique [0002] Immunity is an active defense mechanism of the human body, which is the function of the human body to recognize and eliminate antigenic foreign bodies. Immunity plays a very important role in maintaining physiological and life activities. The immune cells that maintain the immune function in the human body include T cells, B cells, neutrophils, and macrophages. Insufficient immunity or excessive immunity will bring adverse effects to oneself, mainly manifested as loss of appetite, malnutrition, Trance, physical weakness, fatigue, sleep disorders, etc. With the improvement of health care awareness in modern society, people also have higher requirements for the prevent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C235/66C07C231/24A61K36/258A61K36/725A61K36/815A61K31/223A61P37/04A23L33/10A23L33/105C12P13/02C12R1/23C12R1/01C12R1/225
CPCA23V2002/00A61K31/223A61K36/258A61K36/725A61K36/815A23L33/10A23L33/105A61P37/04C07C235/66C12P13/02A61K2300/00A23V2200/324A23V2250/21A23V2250/30
Inventor 刘志刚刘杰刘晓宇
Owner 刘志刚
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