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Extract with effect of alleviating smoking cessation symptoms, and preparation method and application of extract

A technology of extracts and symptoms, applied in the field of extracts with the effect of relieving smoking cessation symptoms and its preparation, can solve the problems that the nature of the action has not been elaborated, and achieve the effects of improving the success rate of smoking cessation, reducing withdrawal symptoms, and reducing pain

Inactive Publication Date: 2020-10-23
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the nature of its toxicity has not been elaborated; in addition, whether Zanthoxylum bungeanum has an effect on the central nervous system in addition to the numbing sensation of taste, there has been no relevant report so far.

Method used

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  • Extract with effect of alleviating smoking cessation symptoms, and preparation method and application of extract
  • Extract with effect of alleviating smoking cessation symptoms, and preparation method and application of extract
  • Extract with effect of alleviating smoking cessation symptoms, and preparation method and application of extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take Zanthoxylum bungeanum, use solvent (water: ethanol: ionic liquid = 2:90:8, volume ratio) to carry out cold soaking for 3 hours, then heat and reflux for extraction, the ratio of solid to liquid is 1:10, each extraction is 2 hours, after the sample is extracted twice The combined extracts are concentrated by a rotary evaporator and then dried to obtain the Zanthoxylum bungeanum extract. Take the above extract, add an appropriate amount of starch, mix evenly, granulate, pack into capsules, and make 1000 capsules to obtain the capsule oral medicine.

Embodiment 2

[0025] Get the Zanthoxylum bungeanum after extracting volatile oil, carry out countercurrent extraction with solvent (water: ethanol: deep eutectic solvent ([C4MIM][BF4])=10:85:5, volume ratio), solid-liquid ratio is 1:50, every time After extracting for 2 hours, the samples were extracted twice, and then the combined extract was concentrated by a rotary evaporator and then dried. Take the above-mentioned extract, add appropriate amount of starch and cyclodextrin, mix evenly, granulate and tablet, and make 1000 tablets to obtain the tablet oral medicine.

Embodiment 3

[0027] Take Zanthoxylum bungeanum, use solvent (water: ethanol: deep eutectic solvent [ChCl-lactic acid (1:2)] = 30:50:20, volume ratio) ultrasonically assisted extraction, the ratio of solid to liquid is 1:1, each extraction 1h , After the sample is extracted twice, the combined extract can be concentrated and then dried. The above-mentioned extract is taken, added into molten polyethylene glycol, stirred evenly, and made into a drop pill, and the oral medicine of the drop pill is obtained.

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Abstract

The invention discloses an extract with the effect of alleviating smoking cessation symptoms, and a preparation method and application of the extract. A mixture of water, ethanol, and ionic liquid inany ratio is used as a solvent, or a mixture of water, ethanol, and a deep eutectic solvent in any ratio is used as a solvent, and Sichuan Pepper or Sichuan Pepper residue is subjected to cold soaking, refluxe extraction, microwave-assisted extraction, ultrasonic-assisted extraction, flash extraction, or countercurrent extraction to obtain the extract with the effect of alleviating the smoking cessation symptoms. The extract can be made into extractum. An application method includes the steps that the extract with the effect of alleviating the smoking cessation symptoms is taken as an effective ingredient and prepared into an oral preparation with appropriate auxiliary materials. A better choice is to take Sichuan Pepper extractum as an effective ingredient to prepare an oral preparation with appropriate auxiliary materials. By preparing the extract into the oral preparations, the withdrawal symptoms of nicotine addicted smokers can alleviated or reduced, smoking quitters can be effectively helped for reducing the pain from smoking cessation, and therefore the success rate of smoking cessation is improved.

Description

technical field [0001] The invention relates to a substance that can help smokers alleviate smoking cessation symptoms, more specifically, the invention relates to an extract capable of alleviating smoking cessation symptoms, its preparation method and application. Background technique [0002] Tobacco dependence is a chronic and highly recurrent addictive disease caused by individuals' continuous intake of nicotine (the main active ingredient in cigarettes). Studies have shown that smoking is not only closely related to heart disease, cancer, digestive system diseases, respiratory diseases, and cardiovascular and cerebrovascular diseases, but also causes miscarriage, fetal dysplasia, and central nervous system dysfunction. According to WHO estimates, there are about 1.1 billion smokers in the world, and about 6 million people die from smoking-related diseases every year, accounting for about 20% of all deaths, resulting in huge medical costs and social burdens. If smoking ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61K9/00A61P25/34
CPCA61K9/0053A61K36/758A61K2236/333A61K2236/39A61K2236/51A61P25/34
Inventor 谭正怀邸多隆
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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