Skin graft used for xenogeneic intermingled transplantation

A technology of xenotransplantation and skin grafts, which is applied in the field of preparation of medical treatment biomaterials, can solve the problems of poor anti-infection ability, no biological activity, difficult long-term repair of wounds, etc., to reduce usage, reduce immune rejection, and reduce supply The effect of area damage

Inactive Publication Date: 2020-11-06
陈翔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the prepared dressing has no biological activity after inactivation treatment, which can temporarily p

Method used

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  • Skin graft used for xenogeneic intermingled transplantation
  • Skin graft used for xenogeneic intermingled transplantation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This embodiment includes the following steps:

[0027] (1) Preparation of pigskin slice 1: select fresh pigskin suitable for xenotransplantation (the fresh pigskin here refers to pigskin that still has biological activity), perform aseptic operation, and use a skin knife to cut out 0.1-1mm thick and complete Large pig skin slices, the resulting skin slices contain pig epidermis and a small amount of dermis, and have biological activity; the complete large pig skin slices are washed with normal saline, and then cut into side lengths by mechanical cutting or laser cutting It is a square block of a cm, where 0.2≤a≤2; in order to keep the skin graft stretched, support materials such as Vaseline gauze can be covered on the cuticle side of the skin graft in advance; biological activity refers to the presence of cellular components in the skin graft, and after transplantation still alive;

[0028] (2) Preparation of autologous skin piece 2: Cut the 0.1mm-1mm thick autologous ...

Embodiment 2

[0040] This embodiment includes the following steps:

[0041] (1) Preparation of pigskin slice 1: select fresh pigskin suitable for xenotransplantation (the fresh pigskin here refers to pigskin that still has biological activity), perform aseptic operation, and cut about 0.1-1mm thick with a skin knife Complete large pig skin slices, the resulting skin slices contain pig epidermis and a small amount of dermis, and have biological activity; complete large pig skin slices are cleaned with normal saline, mechanically or laser cut, at fixed intervals c cm, open a square hole with a side length of d cm (inlaid hole 11) in the large pig skin skin, where 0.2≤c≤2, 0.2≤d≤2, in order to keep the skin stretched, it can be in advance One side of the cuticle of the skin graft is covered with support materials such as vaseline gauze; biological activity means that the cell components in the skin graft exist and can still survive after transplantation;

[0042] (2) Preparation of autologous s...

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Abstract

The invention provides a skin graft used for xenogeneic intermingled transplantation. The skin graft comprises a pigskin graft and an autologous skin graft, and is prepared by adopting the following method: (1) preparation of the pigskin graft; and (2) preparation of the autologous skin graft. According to the invention, a pig serves as a donor, and the donor is wide in source and is processed into a special shape, so a wound surface can be conveniently repaired by embedding and intermingled transplantation of the donor with the autologous skin of a patient in a later period; the current situation of skin source shortage for the patient with large-area skin defects like burns and skin avulsion can be greatly relieved; the injury of a donor site is reduced; the life of the patient is saved;great social value and large industrialization and commercialization values are achieved; and considerable economic values are brought after the skin graft is put into the clinical market.

Description

technical field [0001] The invention relates to a method for preparing a biological material for medical treatment, in particular to a skin graft for heterogeneous mixed transplantation. Background technique [0002] Large areas of skin defects such as burns, skin avulsions, lack of autologous skin sources, and difficulty in wound closure are the main causes of death. Acellular allograft or xenograft skin, synthetic dermal matrix, etc., which are widely used clinically, can temporarily protect the wound or provide a scaffold, but they cannot replace autologous skin transplantation, and have the problem of poor anti-infection ability. [0003] Biologically active cell-containing xenotransplantation is a current research hotspot. Because pigs are easy to breed and are very similar to humans in terms of physiology and metabolism, the possibility of human-pig comorbidities is less likely to occur, involving less ethical and moral disputes, and can be The matching of donor tissu...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/60A61L27/50
CPCA61L27/362A61L27/3695A61L27/50A61L27/60A61L2430/40
Inventor 陈翔何志友魏天虹赵爽粟娟魏红江
Owner 陈翔
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