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Reagent combination, reagent or kit for measuring creatinine content

A reagent set and kit technology, which is applied in the field of reagent combinations, reagents or kits for measuring creatinine content, and can solve problems such as affecting the accuracy of measurement data.

Inactive Publication Date: 2020-11-17
柏定生物工程(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In such a small state, the amount of newly produced creatine can easily affect the accuracy of the measurement data

Method used

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  • Reagent combination, reagent or kit for measuring creatinine content
  • Reagent combination, reagent or kit for measuring creatinine content
  • Reagent combination, reagent or kit for measuring creatinine content

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Prepare Reagent 1 and Reagent 2 at the concentrations shown in the table below:

[0069] Reagent 1:

[0070]

[0071] Reagent 2:

[0072]

Embodiment 2

[0104] Prepare Reagent 1 and Reagent 2 at the concentrations shown in the table below:

[0105] Reagent 1:

[0106]

[0107] Reagent 2:

[0108]

Embodiment 3

[0122] Prepare Reagent 1 and Reagent 2 at the concentrations shown in the table below:

[0123] Reagent 1:

[0124]

[0125]

[0126] Reagent 2:

[0127]

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PUM

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Abstract

The invention relates to the technical field of biology, and particularly relates to a reagent combination, a reagent or a kit for measuring creatinine content. The reagent combination comprises a reagent group 1 and a reagent group 2; the reagent group 1 comprises creatinase, sarcosine oxidase, ascorbic acid oxidase, chromogen and catalase; the reagent group 2 comprises creatinase, 4-aminoantipyrine and peroxidase; and the chromogen is selected from N-(2-hydroxy-3-sulfopropyl)-3, 5-dimethoxyaniline or sodium salt thereof and N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3-5-dimethoxyaniline. An inhibitor is added into the measured reagent, so that generation of neocreatine and creatinine in the process of measuring is blocked, and interference existing in a sample in creatinine detection is lowered.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a reagent combination, reagent or kit for measuring creatinine content. Background technique [0002] Creatinine is a low-molecular nitrogen compound with a molecular weight of 116,000, which is mainly produced by muscle metabolism. In muscle, creatine is mainly slowly formed into creatinine through irreversible non-enzymatic dehydration reaction, and then released into the blood and excreted with urine. Under normal circumstances, the creatinine content of the human body remains basically stable. The normal upper limit of plasma creatinine is around 100 micromol / L. Creatinine is a small molecular substance that can be filtered by the glomerulus, so the concentration change of serum creatinine is mainly determined by the filtration capacity of the glomerulus. As filtration capacity decreases, creatinine concentration increases. Serum creatinine values ​​that are higher than the n...

Claims

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Application Information

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IPC IPC(8): C12Q1/34C12Q1/30C12Q1/28C12Q1/26
CPCC12Q1/26C12Q1/28C12Q1/30C12Q1/34C12Q2326/96G01N2333/90235G01N2333/90683G01N2333/978
Inventor 史福芹
Owner 柏定生物工程(北京)有限公司
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