Unlock instant, AI-driven research and patent intelligence for your innovation.

Antibodies to feline mcdonough sarcoma (FMS)-like tyrosine kinase 3 receptor ligand (FLT3L) and uses thereof for treating autoimmune and inflammatory diseases

An antibody and amino acid technology, applied in allergic diseases, antibody medical components, muscular system diseases, etc., can solve problems such as harmful effects of autoimmune diseases

Pending Publication Date: 2020-11-24
VIELA BIO INC
View PDF38 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Thus, although FLT3-mediated pro-inflammatory survival (e.g., via pDCs and mDCs) is a favorable physiological response in healthy individuals, it may have detrimental effects in autoimmune diseases

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antibodies to feline mcdonough sarcoma (FMS)-like tyrosine kinase 3 receptor ligand (FLT3L) and uses thereof for treating autoimmune and inflammatory diseases
  • Antibodies to feline mcdonough sarcoma (FMS)-like tyrosine kinase 3 receptor ligand (FLT3L) and uses thereof for treating autoimmune and inflammatory diseases
  • Antibodies to feline mcdonough sarcoma (FMS)-like tyrosine kinase 3 receptor ligand (FLT3L) and uses thereof for treating autoimmune and inflammatory diseases

Examples

Experimental program
Comparison scheme
Effect test

example

[0265] The present disclosure is described with reference to the following examples. These examples are illustrative only, and the disclosure should in no way be construed as being limited to these examples, but rather should be construed to cover any and all variations that become apparent as a result of the teaching provided herein.

[0266] Example No. 1. Anti-FLT3L Antibody Generation

[0267] Overview:

[0268] FLT3L is a non-disulfide-linked homodimeric glycoprotein of 65 kDa. Ligand and receptor sequence homologies for human, non-human primate and mouse are shown in Table 2 below.

[0269] Table 2. Identity to human FLT3 and FLT3L

[0270]

[0271] Although the homology of the complete mouse FLT3L protein is only 73%, its binding site to FLT3 is highly conserved among species. Indeed, human FLT3L binds and activates mouse FLT3 and vice versa. FLT3L has structural homology to stem cell factor (SCF or KIT ligand) and colony-stimulating factor 1 (CSF1), but no sign...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Provided herein are anti-FLT3L antibodies and methods of using the antibodies to treat autoimmune and other inflammatory diseases.

Description

Background technique [0001] Autoimmune diseases, which occur when the body's immune system produces autoantibodies, are sadly common. For example, it is estimated that more than 23 million Americans suffer from autoimmune diseases. There are currently more than 80 recognized autoimmune diseases. Specific examples of autoimmune diseases include systemic lupus erythematosus, myositis, primary Sjogren's syndrome, multiple sclerosis, uveitis, psoriasis, and rheumatoid arthritis. [0002] Systemic lupus erythematosus (SLE) is characterized by joint pain, swollen lymph nodes, and a butterfly-shaped rash on the cheeks. In SLE, autoantibodies against healthy tissue attack the patient's immune system, causing inflammation. At the cellular level, SLE patients have autoreactive T and B cells driven by dendritic cells (Palucka A.K. et al., Immunology and Cell Biology (2002) 80:484-488). Sjogren's syndrome is characterized by systemic chronic inflammation of the exocrine organs leading...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K39/00C07K16/40
CPCC07K16/40A61K2039/505A61P37/02C07K16/00C07K2317/24C07K2317/565C07K2317/567C07K2317/76A61P13/12A61P21/00A61P37/00C07K16/243C07K2317/52
Inventor A·汉森肖晓东P·帕夫利克Y·陈R·埃廷格尔
Owner VIELA BIO INC