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Photothermal enhanced photosensitizer based on black phosphorus, and preparation method and application thereof

A photosensitizer, black phosphorus technology, applied in the field of nano-biomedical materials, can solve the problems of difficult to achieve integration of diagnosis and treatment, low tumor cell enrichment, insufficient photothermal concentration, etc., to improve technical feasibility and strong biological imaging. ability, the effect of reducing the dosage of photosensitizers

Inactive Publication Date: 2020-12-15
SHENZHEN HANGUANG TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the present invention provides a photothermally enhanced photosensitizer based on black phosphorus to solve the problems of insufficient photothermal concentration, low degradation safety, high potential harm and low tumor cell enrichment existing in existing photosensitizers , It is difficult to realize the integration of diagnosis and treatment
The present invention also provides a method for preparing a photothermally enhanced photosensitizer based on black phosphorus, so as to solve the defects of complex preparation process and high production cost in existing photosensitizers

Method used

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  • Photothermal enhanced photosensitizer based on black phosphorus, and preparation method and application thereof
  • Photothermal enhanced photosensitizer based on black phosphorus, and preparation method and application thereof
  • Photothermal enhanced photosensitizer based on black phosphorus, and preparation method and application thereof

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Embodiment 1

[0057] The photothermally enhanced photosensitizer based on black phosphorus of the present invention has a simplified structural formula of POM@PEG@BP, where POM is a polyoxometalate, PEG is a polyethylene glycol chain, and BP is a black phosphorus nanosheet. The synthesis of BP nanosheets and the process of in situ self-assembly of POM on BP are as follows: figure 1 as shown in a ( figure 1 POM@BP shown in a is the abbreviation of POM@PEG@BP). In this example, Mo-based POM@PEG@BP is taken as an example. The structure of the photothermally enhanced photosensitizer based on black phosphorus can be divided into three basic units, namely Mo-based POM, SH-PEG-NH 2 and BP, the specific composition and functions are as follows:

[0058] (1) POM

[0059] Mo-based polyoxometalates - polyoxymolybdates, composed of cations (Na + and NH 4 + ) and Keggin-type large anion units.

[0060] Main role: benefiting from protonation-induced hydrogen bonding, acid-responsive self-assembly ...

Embodiment 2

[0090] The preparation process of the photothermally enhanced photosensitizer based on black phosphorus in Example 1 is as follows:

[0091] Step 1: Prepare POM

[0092] 1.684g H 24 Mo 7 N 6 o 24 4H 2 O was dissolved in 5 ml deionized water and stirred at 25 °C for 1 h. 0.106gNaH 2 PO 4 Dissolve in 2.5 ml of deionized water, then pour into the above ammonium molybdate tetrahydrate solution, and then stir for 15 minutes. Subsequently, after washing twice with ethanol and water respectively, 20 ml of ethanol was added to obtain a white precipitate, and the POM powder was collected after freeze-drying for subsequent preparation of a photothermally enhanced photosensitizer based on black phosphorus.

[0093] Step 2: Prepare BP

[0094] IPA (isopropanol) was chosen as the stripping solvent to avoid degradation of BP nanosheets. The BP block was ground and mixed with IPA for liquid phase exfoliation, and 150nm ultra-thin BP nanosheets were obtained by gradient centrifugati...

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Abstract

The invention provides a photothermal enhanced photosensitizer based on black phosphorus. The simple structure formula of the photothermal enhanced photosensitizer based on black phosphorus is POM@PEG@BP; POM is polyoxometallate; PEG is a polyethylene glycol chain; BP is a black phosphorus nanosheet; one end of the polyethylene glycol chain is connected with the black phosphorus nanosheet; and theother end of the polyethylene glycol chain is connected with the polyoxometallate. The invention provides a preparation method and application of the photothermal enhanced photosensitizer based on black phosphorus. The photothermal enhanced photosensitizer based on black phosphorus in the invention is a powerful and intelligent photosensitizer; and the photosensitizer has the effects of automatically identifying tumour and non-tumour cells, automatically assembling, enhancing the light absorption capability and enhancing the photothermal performance and specific accumulation of tumour parts,and also has relatively high biological imaging capability and intelligent tumour cell tracking capability.

Description

technical field [0001] The present invention relates to nano biomedical materials, in particular to a black phosphorus-based photothermally enhanced photosensitizer, the invention also relates to a preparation method of the black phosphorus-based photothermally enhanced photosensitizer, and the present invention also relates to the black phosphorus-based photothermally enhanced photosensitizer Application of heat-enhanced photosensitizer in preparation of tumor diagnosis preparation and tumor treatment preparation. Background technique [0002] Photoexcitation therapy strategies for cancer have attractive advantages of non-invasive approach, low side effects and specificity. Therefore, photodynamic therapy (PDT), photothermal therapy (PTT) and other researches are developing rapidly. Photothermal therapy (PTT) is a promising cancer treatment technique that kills tumor cells by converting light absorbed by photosensitizers into heat at the lesion. For the traditional ideal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/22A61P35/00
CPCA61K41/0052A61K41/0057A61K49/225A61P35/00
Inventor 张家宜王迎威谢建磊康建龙
Owner SHENZHEN HANGUANG TECH CO LTD
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