A kind of antibacterial medical glue material and preparation method thereof
A technology of matrix material and propolis, applied in application, medical science, surgery and other directions, can solve the problems of unsatisfactory strength performance and strength performance, and achieve the effect of improving long-term bonding strength and good antibacterial performance.
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preparation example 1
[0022] The preparation of preparation example 1α-n-butyl cyanoacrylate
[0023] This preparation example is used for preparing required n-butyl cyanoacrylate, specifically comprises the following steps:
[0024] (1) Butyl ester transesterification reaction
[0025] CNCH 2 COOC 2 h 5 +C 4 h 9 OH—C 2 h 5 ONa→CNCH 2 COOC 4 h 9 +C 2 h 5 Oh
[0026] In a 5L three-necked beaker equipped with a stirrer and a thermometer, put 1400ml of ethyl cyanoacetate and 1200ml of n-butanol, turn on the stirring, condense water, add 25g of sodium ethoxide to 40°C and above; heat up to 100°C and the top temperature reaches 78 Start distilling ethanol at -82°C. When the internal temperature reaches 110°C and the top temperature reaches 98-100°C, stop heating and collect about 680ml of ethanol;
[0027] Cool down to an internal temperature of about 50°C, turn on the heating, change the bottle with the vacuum pump to receive n-butanol, the vacuum degree is -0.1MPa, and change the bottle ...
preparation example 2
[0037] Preparation Example 2 The preparation of n-octyl cyanoacrylate
[0038] This preparation example is used for preparing required n-octyl cyanoacrylate, specifically comprises the following steps:
[0039] (1) with step (1) in the preparation example 1;
[0040] (2) with step (2) in the preparation example 1;
[0041] (3) Synthesis of n-octyl α-cyanoacrylate
[0042]
[0043]Add 380ml of methanol-formaldehyde solution and 0.95ml of piperidine into a 5L three-neck flask equipped with a stirrer, dropping funnel, condenser, and water separator. When the temperature in the bottle reaches 40°C or above, start adding cyanoacetic acid After adding 750ml of octyl esters dropwise, collect methanol until the internal temperature reaches 120°C; then add 300ml of petroleum ether dropwise, start dehydration, and speed up stirring. After the water is finished, collect about 300ml of petroleum ether; when the internal temperature reaches 130°C, add 20g of phosphorus pentoxide and ...
Embodiment 1
[0048] The preparation method of antibacterial medical adhesive material described in the present embodiment, comprises the steps:
[0049] (1) According to the mass ratio of 55wt%: 45wt%, take the above-mentioned n-butyl cyanoacrylate and n-octyl α-cyanoacrylate and fully mix to obtain the alkyl α-cyanoacrylate compound; and according to α- Alkyl cyanoacrylate compound: polylactic acid = 70wt%: 30wt% The ratio is fully mixed to obtain a medical gel matrix, which is set aside;
[0050] (2) Add gum arabic airgel particles accounting for 20wt% of the quality of the medical glue matrix and propolis accounting for 25wt% of the quality of the medical glue matrix to the above-mentioned medical glue matrix, fully stir and mix until the gel state, and obtain the antibacterial matrix material, spare;
[0051] (3) above-mentioned base material is placed in the airtight container that choline chloride ionic liquid (accounting for 15wt% of described base material quality) is housed, gets...
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