Anti-infection medical glue material and preparation method thereof

An anti-infection and matrix material technology, which is applied in the field of anti-infection medical adhesive materials, can solve the problems of unsatisfactory strength performance, etc., and achieve the effect of long-term bond strength improvement and good anti-infection performance

Active Publication Date: 2021-01-26
卫纳塞德(北京)医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the addition of polylactic acid materials improves the strength of medical adhesive materials to a certain extent, its strength properties, especially long-term strength properties, are not ideal.

Method used

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  • Anti-infection medical glue material and preparation method thereof
  • Anti-infection medical glue material and preparation method thereof
  • Anti-infection medical glue material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0025] The preparation of preparation example 1α-n-butyl cyanoacrylate

[0026] This preparation example is used for preparing required n-butyl cyanoacrylate, specifically comprises the following steps:

[0027] (1) Butyl ester transesterification reaction

[0028] CNCH 2 COOC 2 h 5 +C 4 h 9 OH—C 2 h 5 ONa→CNCH 2 COOC 4 h 9 +C 2 h 5 Oh

[0029] Put 1400ml of ethyl cyanoacetate and 1200ml of n-butanol into a 5L three-necked beaker equipped with a stirrer and a thermometer, turn on the stirring, condense water, add 25g of sodium ethoxide to 40°C and above; heat up to 100°C and the top temperature reaches 78 Start distilling ethanol at -82°C. When the internal temperature reaches 110°C and the top temperature reaches 98-100°C, stop heating and collect about 680ml of ethanol;

[0030] Cool down to an internal temperature of about 50°C, turn on the heating, change the bottle with the vacuum pump to receive n-butanol, the vacuum degree is -0.1MPa, and change the bottle...

preparation example 2

[0040] Preparation Example 2 The preparation of n-octyl cyanoacrylate

[0041] This preparation example is used for preparing required n-octyl cyanoacrylate, specifically comprises the following steps:

[0042] (1) with step (1) in the preparation example 1;

[0043] (2) with step (2) in the preparation example 1;

[0044] (3) Synthesis of n-octyl α-cyanoacrylate

[0045]

[0046]Add 380ml of methanol-formaldehyde solution and 0.95ml of piperidine into a 5L three-neck flask equipped with a stirrer, dropping funnel, condenser, and water separator. When the temperature in the bottle reaches 40°C or above, start adding cyanoacetic acid After adding 750ml of octyl esters dropwise, collect methanol until the internal temperature reaches 120°C; then add 300ml of petroleum ether dropwise, start dehydration, and speed up stirring. After the water is finished, collect about 300ml of petroleum ether; when the internal temperature reaches 130°C, add 20g of phosphorus pentoxide and ...

Embodiment 1

[0051] The preparation method of the anti-infection medical adhesive material described in this embodiment comprises the following steps:

[0052] (1) According to the mass ratio of 55wt%: 45wt%, take the above-mentioned n-butyl cyanoacrylate and n-octyl α-cyanoacrylate and fully mix to obtain the alkyl α-cyanoacrylate compound; and according to α- Alkyl cyanoacrylate compound: polylactic acid = 70wt%: 30wt% The ratio is fully mixed to obtain a medical gel matrix, which is set aside;

[0053] (2) Add the gum arabic airgel particles accounting for 20wt% of the mass of the medical gum matrix in the above-mentioned medical gum matrix, and the dandelion juice (directly squeeze the juice with dandelion) accounting for 25wt% of the quality of the medical gum matrix, fully stir and mix Homogenize to a gel state to obtain an anti-infection matrix material for subsequent use;

[0054] (3) above-mentioned base material is placed in the airtight container that choline chloride ionic liq...

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Abstract

The invention belongs to the technical field of biomedical materials, particularly relates to an anti-infection medical glue material, and further discloses a preparation method of the anti-infectionmedical glue material. According to the anti-infection medical glue material, an alpha-alkyl cyanoacrylate compound and polylactic acid serve as a mixed medical glue matrix, so that a good medical glue matrix material is obtained; meanwhile, plant anti-infection components are added to serve as an anti-infection agent, so that good anti-infection performance is obtained; aerogel particles are added to improve the long-term bonding performance of the medical glue matrix material; and CO2 supercritical fluid carries selected ionic liquid to swell and modify the medical glue matrix material, so that the bonding performance, especially the long-term bonding strength, of the whole medical glue material is greatly improved, and the medical glue material is more suitable for clinical application.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular relates to an anti-infection medical adhesive material, and further discloses a preparation method thereof. Background technique [0002] Medical glue refers to the preparation, material or substance that can adhere to the surface or make the surface bond in the medical application. It belongs to the special functional adhesive of biomedicine. It is mainly used for local adhesion and repair of organs or tissues. Traditional suturing, or the combination and positioning of tissues and blood vessels for closure and other technical fields, in addition to the usual bonding and mechanical functions, also has biomedical functions. Compared with traditional methods such as suturing and stapling, the use of medical glue can effectively shorten the operation time and significantly reduce the pain of patients. It is the preferred material for medical operations at present. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00A61L24/08
CPCA61L24/046A61L24/00A61L24/0005A61L24/0015A61L24/001A61L24/08A61L2300/30A61L2300/404C08L67/04C08L5/00
Inventor 王威田霞张俊杰张怡婷王占光梁永菡刘冲李俊超
Owner 卫纳塞德(北京)医疗科技有限公司
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