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Traditional Chinese medicine compound preparation for preventing and treating thrombocytopenia after radiochemotherapy and preparation method

A technology of compound preparations and platelets, which is applied in the direction of medical formulas, medical preparations containing active ingredients, blood diseases, etc., can solve the problems of no obvious advantages, increased platelets, and long treatment cycle, so as to prevent and treat thrombocytopenia, adjust and supplement Liver and kidney, convenient effect

Inactive Publication Date: 2021-01-22
JIANGYIN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems in the research of TCM treatment: there is no obvious short-term advantage in simple TCM treatment compared with Western medicine treatment, and more importantly, most TCM medicines are mainly used to treat thrombocytopenia after chemotherapy, and there are few preventive medications, so the development and rationality Selecting drugs to prevent thrombocytopenia, giving full play to the advantages of "preventive treatment" of traditional Chinese medicine, and ensuring the normal progress of chemotherapy cycles should be an important direction for future development
[0006] Therefore, in view of the problems that Western medicine has no anti-thrombocytopenia after radio-chemotherapy, the existing therapeutic drugs have long treatment period, high cost, and many adverse reactions, we seek a method suitable for the prevention and treatment of post-radio-chemotherapy thrombocytopenia, which can effectively increase Platelets, definite curative effect, easy to use, mild side effects, low-cost traditional Chinese medicine compound preparations are necessary

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]A traditional Chinese medicine compound preparation for preventing and treating thrombocytopenia after radiotherapy and chemotherapy is made of the following raw materials in weight units: 30 grams of Selaginella chinensis, 10 grams of donkey-hide gelatin, 10 grams of red dates, 10 grams of antler gum, 30 grams of madder, 30 grams of stone reed, 30 grams of ink drought 30 grams of lotus and 50 grams of peanut shells.

[0029] A preparation method of a traditional Chinese medicine compound preparation for preventing and treating thrombocytopenia after radiotherapy and chemotherapy, comprising the following steps:

[0030] 1) Take 30 grams of Selaginella chinensis, 10 grams of red dates, 30 grams of madder, 30 grams of stone reed, 30 grams of Eclipta chinensis and 50 grams of peanut shells to remove impurities, wash them with clean water, then place them in a ventilated place, and let them air dry naturally for later use;

[0031] 2) Put the washed and air-dried medicinal ...

Embodiment 2

[0036] A traditional Chinese medicine compound preparation for preventing and treating thrombocytopenia after radiotherapy and chemotherapy, made of the following raw materials in weight units: 30 grams of Selaginella, 10 grams of donkey-hide gelatin, 10 grams of red dates, 10 grams of antler gum, 30 grams of madder, 30 grams of Shiwei, ink Eclipta 30 grams and peanut shells 50 grams.

[0037] A preparation method of a traditional Chinese medicine compound preparation for preventing and treating thrombocytopenia after radiotherapy and chemotherapy, comprising the following steps:

[0038] 1) Take 30 grams of Selaginella chinensis, 10 grams of red dates, 30 grams of madder, 30 grams of stone reed, 30 grams of Eclipta chinensis and 50 grams of peanut shells to remove impurities, wash them with clean water, then place them in a ventilated place, and let them air dry naturally for later use;

[0039] 2) Put the washed and air-dried medicinal materials in step 1) into a casserole, ...

experiment example

[0044] 1. Experiments on the prevention and treatment of thrombocytopenia caused by chemotherapy

[0045] Experimental method: Select 80 patients with newly diagnosed advanced non-small cell lung cancer confirmed by pathology or cytology in Jiangyin People's Hospital from January 2016 to January 2018, aged 31-73 years, ECOG score 0-2 points, The estimated survival time was >3 months, and they were randomly divided into two groups, of which 40 cases in the control group were given standard AP / TP / GP chemotherapy; The method of taking the traditional Chinese medicine granules is to wash 400ml of the granules prepared in Example 1 of the present invention with boiled water, take them twice in the morning and evening, 1 hour after meals, 200ml each time, and take 30 days as a course of treatment.

[0046] After two courses of chemotherapy, the control group: 6 cases with grade I thrombocytopenia, 3 cases with grade II thrombocytopenia, 2 cases with grade III thrombocytopenia, and 2...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine compound preparation for preventing and treating thrombocytopenia after radiochemotherapy. The traditional Chinese medicine compound preparationis prepared from the following raw materials by weight: 30g of herba selaginellae, 10g of donkey-hide gelatin, 10g of dried red dates, 10g of deer-horn gelatin, 30g of radix rubiae, 30g of herba pyrrosiae, 30g of herba ecliptae and 50g of peanut coats. According to the traditional Chinese medicine compound preparation, present problems that Western medicines are free of medicines for preventing the thrombocytopenia after radiochemotherapy and the existing treatment medicines are long in treatment cycle, high in cost and plenty in adverse reactions are solved; the traditional Chinese medicine compound preparation is suitable for preventing and treating the thrombocytopenia after radiochemotherapy; and through clinical application for years, the traditional Chinese medicine compound preparation can be used for effectively preventing the thrombocytopenia after radiochemotherapy and increasing platelets, is definite in treatment effect, convenient in use and little in adverse reaction andhas a broad market prospect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation for preventing and treating thrombocytopenia after radiotherapy and chemotherapy and a preparation method thereof. Background technique [0002] Nowadays, malignant tumors have become the main cause of serious threats to human life and health, ranking second in the cause of disease death, and even rising to the first in some countries. Chemoradiotherapy is the most important and commonly used method in the clinical treatment of malignant tumors. However, some adverse reactions often occur during radiotherapy and chemotherapy, such as bone marrow suppression (leukopenia, thrombocytopenia), low systemic immune function, and easy co-infection. [0003] Thrombocytopenia (Chemotherapy Induced Thrombocytopenia, CIT) is a common side effect of chemotherapy. CIT refers to the inhibitory effect of chemotherapy drugs on the bone marrow, especially on macrophages, resulting in a lower p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P7/04A61K35/32A61K35/36
CPCA61K36/11A61K35/36A61K36/725A61K35/32A61K36/74A61K36/28A61K36/48A61P7/04
Inventor 沈伟生奚蕾曾洁刘雄伟
Owner JIANGYIN PEOPLES HOSPITAL
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