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Temperature sensor based on precious metal nanoparticles and preparation method thereof

A technology of temperature sensor and gold nanoparticles, which can be used in thermometers, thermometers, instruments, etc. with physical/chemical changes, and can solve the problems of quenching, high equipment requirements, and large measurement temperature range.

Active Publication Date: 2022-08-02
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] When the material prepared by the above method is used for temperature sensing, it is necessary to perform fluorescence detection on the measured object, which is complicated in process and requires high equipment.
At the same time, the characteristic fluorescence used to respond to temperature conditions is easily disturbed by natural light, resulting in quenching, resulting in sensor failure
In addition, similar to most other nanoparticle-based temperature sensors in the prior art, it only has a fixed temperature response range, and the measurement temperature range is large (between 20-60°C), and the temperature control accuracy is poor

Method used

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  • Temperature sensor based on precious metal nanoparticles and preparation method thereof
  • Temperature sensor based on precious metal nanoparticles and preparation method thereof
  • Temperature sensor based on precious metal nanoparticles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Determination of T of double-stranded DNA in different proportions of alcohol solvent m value:

[0079] Dissolve 1.5μM DNA double-stranded in ethanol or isopropanol solutions with volume percentages of 0, 5%, 10%, 20%, 30%, 40%, respectively, and determine the T of double-stranded DNA in the solution by RT-qPCR m value, the results are shown in the attached figure 1 , it can be seen that with the increase of ethanol / isopropanol content, the T of DNA duplex m The value gradually decreases, and it can be estimated that when the system contains 25% isopropanol, the T of the double chain m When the value is reduced to about 35°C, temperature regulation is performed with a sensor solution system containing 25% isopropanol, and the resulting sensor should respond to temperature in the range of 30-35°C.

Embodiment 2

[0081] The sensor solution system was prepared by the following steps:

[0082] (1) Synthesis of gold nanorods:

[0083] The first step: synthetic seed solution: 5.0mL, 0.00050M HAuCl 4 Add to 5mL, 0.20M CTAB while stirring, speed up the stirring speed and quickly add 0.60mL, 0.010M ice NaBH 4 , the solution turned brown, continue to vigorously stir the seed solution for 2 min, stop stirring and keep at 25 °C.

[0084] Step 2: Prepare growth solution: at 25°C, add 1.5mL, 0.0040M AgNO 3 The solution was added to 50mL, 0.20M CTAB, and 50mL, 0.0010M HAuCl was added to the mixed solution 4 , and stirred gently, then 700 μL of 0.0788M ascorbic acid was added, and the color of the solution gradually changed from dark yellow to colorless.

[0085] The third step: growth of gold nanorods: at 30°C, add 120 μL of seed solution to the growth solution, mix well and let stand for growth for 6 hours to obtain a solution of gold nanorods.

[0086] (2) Surface modification of DNA on gold...

Embodiment 3

[0094] The sensor solution system is prepared by the same process as in Example 2, except that step (1) is the following process of synthesizing gold nanospheres:

[0095] Dissolve 1g of chloroauric acid in 100mL of ultrapure water to obtain an aqueous solution of chloroauric acid, add 1mL to 95mL of ultrapure water, stir and heat to a slight boil, then add 4mL to obtain 1g of sodium citrate dissolved in 100mL of ultrapure water. 1 wt% sodium citrate solution, and keep boiling, when the color of the solution turns red, continue heating for 5-20 min, then stop heating, keep stirring until the solution drops to room temperature, and obtain a gold nanosphere solution. The dispersed state of the temperature sensor constructed by gold nanospheres is as follows: Figure 12 The electron microscope image of the temperature sensor constructed by gold nanospheres after agglomeration is shown in Figure 13 .

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Abstract

The invention discloses a temperature sensor based on precious metal nanoparticles and a preparation method thereof. Wherein the temperature sensor comprises a noble metal nanoparticle whose surface is modified with a first DNA segment, a second DNA segment complementary to the first DNA segment, an alcohol solvent and a salt solution. The temperature sensor of the present invention has excellent biocompatibility, temperature responsiveness and temperature measurement sensitivity, and can be applied to various aspects such as disease diagnosis and drug delivery.

Description

technical field [0001] The present invention relates to the technical field of nanoparticle-based temperature sensors. Background technique [0002] Most of the current temperature sensors rely on temperature-sensitive materials, which are often harmful to the human body. Some temperature sensors that have been improved in this regard need to use other instruments for temperature measurement, which greatly limits the temperature. practical application of the sensor. [0003] For example, Chinese patent CN106010509 discloses a ratiometric temperature sensor based on fluorescent silicon nanoparticles, which is prepared by modifying the temperature-responsive rhodamine B isothiocyanate on the surface of fluorescent silicon nanoparticles through covalent bonds. A silicon nanocomposite material that can generate different fluorescence reactions with temperature changes. As the temperature increases, the fluorescence of rhodamine isothiocyanate B in the composite material gradual...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01K11/12
CPCG01K11/12
Inventor 王国庆王璐阳李钰金韩肖田永帅
Owner OCEAN UNIV OF CHINA