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Temperature sensor based on precious metal nanoparticles and production method thereof

A temperature sensor and gold nanoparticle technology, which can be used in thermometers, thermometers, instruments, etc. with physical/chemical changes, and can solve problems such as high equipment requirements, complex processes, and poor temperature control accuracy.

Active Publication Date: 2021-05-04
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] When the material prepared by the above method is used for temperature sensing, it is necessary to perform fluorescence detection on the measured object, which is complicated in process and requires high equipment.
At the same time, the characteristic fluorescence used to respond to temperature conditions is easily disturbed by natural light, resulting in quenching, resulting in sensor failure
In addition, similar to most other nanoparticle-based temperature sensors in the prior art, it only has a fixed temperature response range, and the measurement temperature range is large (between 20-60°C), and the temperature control accuracy is poor

Method used

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  • Temperature sensor based on precious metal nanoparticles and production method thereof
  • Temperature sensor based on precious metal nanoparticles and production method thereof
  • Temperature sensor based on precious metal nanoparticles and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Determination of T of double-stranded DNA in different proportions of alcohol solvents m value:

[0079] Prepare 1.5 μM double-stranded DNA and dissolve them in 0, 5%, 10%, 20%, 30%, 40% ethanol or isopropanol solutions by volume, and measure the T of the double-stranded DNA in the solution by RT-qPCR m value, the results are attached figure 1 As shown, it can be seen that with the increase of ethanol / isopropanol content, the T m The value decreases gradually, and it can be estimated that when the system contains 25% isopropanol, the double-chain T m If the value is reduced to about 35°C, the sensor solution system containing 25% isopropanol is used for temperature control, and the obtained sensor should be able to respond to the temperature in the range of 30-35°C.

Embodiment 2

[0081] Prepare the sensor solution system by the following steps:

[0082] (1) Synthesis of gold nanorods:

[0083] The first step: synthetic seed solution: 5.0mL, 0.00050M HAuCl 4 Add to 5mL, 0.20M CTAB and stir at the same time, after increasing the stirring speed, quickly add 0.60mL, 0.010M ice NaBH 4 , the solution turned brownish-yellow, and continued to stir the seed solution vigorously for 2 minutes, then stopped stirring and kept it at 25°C.

[0084] Step 2: Preparation of growth solution: at 25°C, 1.5mL, 0.0040M AgNO 3 The solution was added to 50mL, 0.20M CTAB, and 50mL, 0.0010M HAuCl was added to the mixed solution 4 , and stirred gently, then added 700 μL, 0.0788M ascorbic acid, at this time the color of the solution gradually changed from dark yellow to colorless.

[0085] The third step: the growth of gold nanorods: add 120 μL of seed solution to the growth solution at 30° C., mix well and let it grow for 6 hours to obtain a gold nanorod solution.

[0086] (...

Embodiment 3

[0094] Prepare the sensor solution system by the same process as in Example 2, the only difference is that step (1) is the following process of synthesizing gold nanospheres:

[0095] Dissolve 1g of chloroauric acid in 100mL of ultrapure water to obtain an aqueous solution of chloroauric acid, take 1mL and add it to 95mL of ultrapure water, stir and heat to a slight boil, then add 4mL to obtain by dissolving 1g of sodium citrate in 100mL of ultrapure water 1wt% sodium citrate solution, and keep boiling, when the color of the solution turns red, continue heating for 5-20min, stop heating, keep stirring until the solution drops to room temperature, and obtain a gold nanosphere solution. The dispersion state of the temperature sensor constructed by gold nanospheres is as follows: Figure 12 As shown, the electron microscope image of the temperature sensor constructed by gold nanospheres after agglomeration is as follows Figure 13 .

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Abstract

The invention discloses a temperature sensor based on precious metal nanoparticles and a production method thereof. The temperature sensor comprises precious metal nanoparticles with a surface modified with a first DNA chain segment, a second DNA chain segment complementary with the first DNA chain segment, an alcohol solvent and a salt solution. The temperature sensor has excellent biocompatibility, temperature responsiveness and temperature measurement sensitivity, and can be applied to multiple aspects such as disease diagnosis, drug delivery and the like.

Description

technical field [0001] The present invention relates to the technical field of nanoparticle-based temperature sensors. Background technique [0002] Most of the current temperature sensors rely on temperature-sensitive materials. These materials are often harmful to the human body. However, some temperature sensors that have made improvements in this regard often need the help of other instruments when measuring temperature, which greatly limits the temperature. Practical applications of sensors. [0003] For example, Chinese patent CN106010509 discloses a ratiometric temperature sensor based on fluorescent silicon nanoparticles, which is prepared by covalently modifying temperature-responsive rhodamine B isothiocyanate on the surface of fluorescent silicon nanoparticles. A silicon nanocomposite material that can produce different fluorescence reactions with temperature changes. As the temperature increases, the fluorescence of rhodamine B isothiocyanate in the composite ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01K11/12
CPCG01K11/12
Inventor 王国庆王璐阳李钰金韩肖田永帅
Owner OCEAN UNIV OF CHINA