Anti-hepatic fibrosis traditional Chinese medicine compound composition and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problem that there is no anti-liver fibrosis effect, and achieve the effects of inhibiting the progress of liver fibrosis, preventing bleeding, and improving Qi and Yin deficiency.

Inactive Publication Date: 2021-05-07
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, currently there are different opinions on the syndrome differentiation and classification of liver fibrosis, there ...

Method used

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  • Anti-hepatic fibrosis traditional Chinese medicine compound composition and application thereof
  • Anti-hepatic fibrosis traditional Chinese medicine compound composition and application thereof
  • Anti-hepatic fibrosis traditional Chinese medicine compound composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Formula 1 Astragalus 20g Radix Pseudostellariae 10g Angelica 10g Ligustrum lucidum 10g Poria cocos 25g Stir-fried Atractylodes macrocephala 10g Chenpi 8g Wine Scutellaria baicalensis 8g Roasted licorice 5g

Embodiment 2

[0042] Example 2: Formula 2 Astragalus 25g Radix Pseudostellariae 15g Angelica 12g Ligustrum lucidum 10g Poria cocos 25g Stir-fried Atractylodes macrocephala 10g Chenpi 8g Wine Scutellaria baicalensis 8g Roasted licorice 3g

Embodiment 3

[0043] Example 3: Formula 3 Astragalus 30g Radix Pseudostellariae 10g Angelica 10g Ligustrum lucidum 10g Poria cocos 30g Stir-fried Atractylodes macrocephala 10g Chenpi 10g Wine Scutellaria baicalensis 10g Roasted licorice 3g

[0044] The preparation methods of the above three formulations are all implemented according to the following methods:

[0045] (1) Take the crude drug raw material of each dose of medicinal material of the compound Chinese medicine composition, add water of 10 times the weight of the crude drug, after boiling, filter out the first medicinal liquid after decocting for 60 minutes; add 9 times the weight of the crude drug amount of water, decocting for 45 minutes, and then filter out the second medicinal solution; then add water with an amount 8 times the weight of the raw material drug, and decoct for 40 minutes, and then filter out the third medicinal solution;

[0046] (2) Combine the first medicinal liquid, the second medicinal liquid, and the third m...

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Abstract

The invention discloses an anti-hepatic fibrosis traditional Chinese medicine compound composition and application thereof The traditional Chinese medicine compound composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-30 parts of astragalus membranaceus, 10-30 parts of radix pseudostellariae, 5-15 parts of angelica sinensis, 5-15 parts of glossy privet fruit, 5-15 parts of poria cocos, 10-30 parts of roasted rhizoma atractylodis macrocephalae, 5-15 parts of pericarpium citri reticulatae, 5-15 parts of wine-processed scutellaria baicalensis and 3-10 parts of honey-fried licorice root. According to the pathogenesis of hepatic fibrosis, a syndrome differentiation and treatment method is adopted, a prescription is screened in combination with pharmacological experiments, and after the medicines in the prescription are scientifically compatible, the traditional Chinese medicine composition has a good liver protection effect on chronic and acute hepatic failure patients clinically, has a good prevention and treatment effect on hepatic fibrosis in vivo, inhibits proliferation of activated hepatic stellate cells in vitro, has the efficacy of preventing liver cell injury, has a good anti-hepatic fibrosis effect, is a promising traditional Chinese medicine compound, and has a good market promotion value.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine compound with anti-hepatic fibrosis effect and application thereof. Background technique [0002] Liver fibrosis is a common pathological process in the development of various chronic liver diseases. Various reasons lead to excessive proliferation and abnormal deposition of extracellular matrix components in liver tissue, which in turn causes abnormal changes in liver structure or function. Dysfunction and failure seriously endanger life and health. Delaying or even reversing liver fibrosis is of great significance to reducing the occurrence of serious complications and improving the quality of life of patients. [0003] As the main organ of the disease, the liver has its own unique physiological characteristics. The body is yin and uses yang, which stores blood while the body yin conserves liver qi. The movement and transformation of...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P1/16
CPCA61K36/481A61K36/36A61K36/232A61K36/638A61K36/076A61K36/284A61K36/752A61K36/539A61K36/484A61P1/16A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 郑仕中谭善忠张峰王飞虾陈利连娜琦
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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