Application of TDGF-1 (teratocarcinoma-derived growth factor-1) truncated micro-molecule polypeptide in anti-hepatic fibrosis

A TDGF-1, anti-hepatic fibrosis technology, applied in the field of biomedicine, can solve problems such as functional limitations
CN110590929AActive Publication Date: 2019-12-20JILIN UNIV FIRST HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JILIN UNIV FIRST HOSPITAL
Publication Date
2019-12-20

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Abstract

The invention discloses an application of TDGF-1 (teratocarcinoma-derived growth factor-1) truncated micro-molecule polypeptide in anti-hepatic fibrosis. An experiment proves that the TDGF-1 truncatedmicro-molecule polypeptide has the capabilities of blocking a TGF(transforming growth factor)-[beta] signal pathway and lowering [alpha]-SMA (smooth muscle action) expression in a hepatic stellate cell and is an ideal polypeptide medicine for anti-fibrosis treatment. Because the TDGF-1 truncated micro-molecule polypeptide disclosed by the invention lacks a tumor-prompted structural domain, and therefore, the TDGF-1 truncated micro-molecule polypeptide is safe in the anti-fibrosis application, and also has a good market application prospect.
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Description

technical field

[0001] The invention belongs to the field of biomedicine and relates to the application of TDGF-1 truncated small molecular polypeptide in anti-hepatic fibrosis. Background technique

[0002] Liver fibrosis is a pathological change common to almost all chronic liver diseases progressing to the end stage, and its essence is the fibrous tissue scar after liver inflammation and necrosis. Chronic liver diseases that lead to liver fibrosis include alcoholic liver disease, nonalcoholic steatohepatitis (NASH), and chronic hepatitis caused by viral infection. If the disease continues to progress, liver fibrosis will develop into cirrhosis and liver cancer. Therefore, timely and active intervention in patients with liver fibrosis is very important to reduce the incidence of end-stage liver disease.

[0003] The essence of liver fibrosis is a scar reaction, which can be caused by various liver injuries, including poisoning, metabolism and virus attack. Underlying th...

Claims

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