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Application of Arenaria kansuensis Maxim

A unique and versatile technology, applied in the field of anti-hepatic fibrosis extracts, can solve the problems of less patients with secondary liver biopsy, lack of control, and less standardized clinical research

Inactive Publication Date: 2020-09-11
LINYI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There have been clinical reports in the world that treat the cause of the disease, such as the antiviral drug tenofovir disoproxil, which can reverse liver fibrosis and cirrhosis, but the sample size of this study is relatively small, there is no control, and the second liver biopsy fewer patients
Some Chinese patent medicines in China have shown certain anti-hepatic fibrosis effects and are used in clinical treatment, such as Anluo Huaxian Pills, Fufang Biejia Ruangan Tablets, Fuzheng Huayu Capsules, etc. Clear, less standardized clinical research and other issues
Most drugs (such as polyene phosphatidylcholine, obeticholic acid, silymarin, glycyrrhizic acid preparations and glucocorticoids, etc.) have shown certain anti-hepatic fibrosis effects in animal experiments, but the specific mechanism of action is unknown and accompanied by There are certain side effects and drug resistance, so further in-depth research is needed to find alternative therapeutic drugs

Method used

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  • Application of Arenaria kansuensis Maxim
  • Application of Arenaria kansuensis Maxim
  • Application of Arenaria kansuensis Maxim

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of the target site AS2 of the ethyl acetate extract of Gansu fleas is as follows:

[0035] (1) Dry and pulverize the whole plant of Gansu fleas, after sieving, take 2 kg of powder and extract it with 95% ethanol at room temperature, the ratio of solid to liquid is 1:10, and extract 3 times, each time for 8 hours;

[0036] (2) Combine the extracts, concentrate under reduced pressure to form an extract, dissolve the extract in 2L of water, and extract (2L×3) with petroleum ether, ethyl acetate and n-butanol respectively, and extract 3 times with each extractant. The ethyl acetate extract was concentrated and dried to obtain the ethyl acetate extract;

[0037] (3) The ethyl acetate extract part is processed in C18SPE in stages, first eluted with 60% methanol-water to remove the impurity part AS1, then eluted with 80% methanol-water, and collected 80% methanol-water wash The product is removed to obtain the target site AS2.

[0038] Each part can be...

Embodiment 2

[0041] (1) Dry and pulverize the whole plant of Gansu fleas, and after sieving, take 2kg of the powder and extract it with ethyl acetate, the ratio of solid to liquid is 1:10, and extract 3 times in total, each time for 8 hours;

[0042] (2) The above extract is processed in C18SPE in sections, first eluted with 60% methanol-water, then eluted with 80% methanol-water, and the eluted product of 80% methanol-water is collected to obtain the ethanol extract target site.

Embodiment 3

[0044] The whole plant of Gansu fleas is dried in the shade and crushed. After sieving, take 2kg of the powder and extract it with 95% ethanol at room temperature. The ratio of solid to liquid is 1:10. It is extracted 3 times for 8 hours each time. The extracts are combined and concentrated to obtain ethanol. Extract.

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Abstract

The invention discloses an anti-hepatic fibrosis extract and an application thereof, and provides an application of Arenaria kansuensis Maxim or an extract thereof to preparation of products for preventing and / or treating hepatic fibrosis diseases. Animal experiments show that the Arenaria kansuensis Maxim or the extract thereof has an exact anti-hepatic fibrosis effect, thereby being capable of being used for preparing products for preventing and / or treating the hepatic fibrosis diseases.

Description

technical field [0001] The invention relates to the technical field of prevention and treatment of liver fibrosis, in particular to an anti-hepatic fibrosis extract and its application. Background technique [0002] Liver fibrosis is a disease in which the extracellular matrix (ECM) and connective tissue abnormally accumulate and proliferate in the liver, thereby destroying the normal structure and physiological functions. Alcoholic fatty liver disease and autoimmune liver disease, etc.) are the only way to develop cirrhosis and liver cancer. As of 2019, there are many clinical research reports on liver fibrosis, but there is no cure so far. For patients with advanced liver fibrosis (cirrhosis or liver cancer), liver transplantation is the ultimate life-saving straw, but limited liver resources and transplantation The subsequent immune rejection is still a huge problem in liver transplantation. [0003] There have been clinical reports in the world that treat the cause of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/36A61P1/16B01J20/281G01N30/02G01N30/06G01N30/34G01N30/36G01N30/74G01N30/86
CPCA61K36/36A61K2236/333A61K2236/55A61P1/16G01N30/02G01N30/06G01N30/34G01N30/36G01N30/48G01N30/74G01N30/8679
Inventor 崔玉磊沈娜辛化伟王振李春雷
Owner LINYI UNIVERSITY
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