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Pharmaceutical compositions for treating sepsis and application of pharmaceutical compositions

A composition and technology for sepsis, which is applied in the direction of drug combination, pharmaceutical formula, antibacterial drugs, etc., can solve the problem of unclear active ingredients of sepsis

Active Publication Date: 2021-06-04
TIANJIN CHASE SUN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Xuebijing Injection is prepared from Chinese herbal medicines, and the main medicinal ingredients for sepsis are still unclear. It is still necessary to extract and refine a variety of Chinese herbal medicines to prepare a pharmaceutical composition for treating sepsis.

Method used

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  • Pharmaceutical compositions for treating sepsis and application of pharmaceutical compositions
  • Pharmaceutical compositions for treating sepsis and application of pharmaceutical compositions
  • Pharmaceutical compositions for treating sepsis and application of pharmaceutical compositions

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Experimental program
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preparation example Construction

[0030] In the present invention, the preparation method of the pharmaceutical composition preferably includes the following steps:

[0031] It is obtained by mixing hydroxysafflor yellow A, paeoniflorin and paeonifloride according to the above mass ratio.

[0032] When the pharmaceutical composition includes seven kinds, it is obtained by mixing hydroxysafflor yellow A, paeoniflorin, paeoniflorin, oxidized paeoniflorin, ligustonin I, danshensu sodium and ferulic acid according to the above mass ratio.

[0033] The invention provides the application of the pharmaceutical composition in the preparation of medicine for treating sepsis. Application of the pharmaceutical composition in treating sepsis.

[0034] In the present invention, the pharmaceutical composition is preferably used in the preparation of a drug for inhibiting the expression of IL-6, Foxp3, CTLA-4 and / or HMGB1 in sepsis. The experimental results show that at the cell level and animal level, the control group co...

Embodiment 1

[0044] 1. Experimental materials

[0045] Clean grade SD rats (half male and female), 180-220g; hydroxysafflor yellow A, paeoniflorin, paeonifloride and danshenin sodium were purchased from Shanghai Tongtian Biotechnology Co., Ltd.; oxidized paeoniflorin, chuanxiong Lactone I and ferulic acid were purchased from Dingrui Chemical (Shanghai) Co., Ltd., normal saline (0.9% sodium chloride injection).

[0046] 2. Experimental method

[0047] 80 animals (half male and half male) were screened according to animal weight gain, diet, and activity during the adaptation period to enter this experiment, and were divided into 4 groups by weight block method, with 20 animals in each group, half male and half male.

[0048] The concentration of each component in the three-component medicine: hydroxysafflor yellow A 30mg / ml, paeoniflorin 40mg / ml, paeoniflorin 4mg / ml. The liquid preparation method is as follows: weigh (3.0g hydroxysafflower yellow A, 4.0g paeoniflorin, 0.4g paeoniflorin) re...

Embodiment 2

[0058] Evaluation of the effects of three-component drugs and seven-component drugs on the release of IL-6 from rat peritoneal macrophages stimulated by LPS

[0059] 1. Experimental materials

[0060] Male clean grade SD rats (180~220g), endotoxin (LPS), hydroxysafflor yellow A, paeoniflorin, paeonifloride glycoside, oxidized paeoniflorin, ligustonin I, danshensu sodium, ferulic acid , RPMI-1640 medium, 24-well plate, IL-6ELISA kit.

[0061] 2. Experimental method

[0062] The specific method for isolating peritoneal macrophages of male SD rats is as follows: male SD rats were fasted for 12 hours before operation, the abdominal cavity was opened after anesthesia, 10 mL of pre-cooled PBS solution was injected into the abdominal cavity, and the abdominal wall was gently pressed with fingers to make the liquid in the abdominal cavity flow. Draw the fluid in the peritoneal cavity and inject it into the sterile tube, and then lavage once with 10 mL of pre-cooled PBS solution, an...

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Abstract

The invention provides pharmaceutical compositions for treating sepsis and application of the pharmaceutical compositions, and belongs to the technical field of chemical drugs. The invention provides a pharmaceutical composition containing three components, namely hydroxysafflor yellow A, paeoniflorin and albiflorin, and further provides a pharmaceutical composition containing seven components, namely hydroxysafflor yellow A, paeoniflorin, albiflorin, oxypaeoniflorin, senkyunolide I, salvianic acid A sodium and ferulic acid. The cell level and the animal level prove that the two pharmaceutical compositions have the efficacy of effectively treating sepsis, and meanwhile, the drug toxicity experiment shows that the drug has relatively high safety. The pharmaceutical compositions provided by the invention are medicinal components of Xuebijing injection and can be used for clinically treating sepsis.

Description

technical field [0001] The invention belongs to the technical field of chemical medicines, and in particular relates to a pharmaceutical composition for treating sepsis and its application. Background technique [0002] Sepsis is a fatal organ dysfunction caused by an imbalanced host response to infection. The severe condition and high fatality rate are the main causes of death in critically ill patients. For many years, antibiotics, antiviral drugs, and vasopressor drugs have been used in the traditional treatment of sepsis, but there are not enough specific drugs targeting the pathogenesis of sepsis into clinical practice. How to timely correct the systemic inflammatory response, coagulation dysfunction and immune dysfunction during the occurrence and development of sepsis, restore the body's pro-inflammatory-anti-inflammatory dynamic balance as soon as possible, and effectively improve the prognosis of patients has become an urgent need in the research and development of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/7034A61K31/351A61K31/365A61K31/192A61P31/04A61P31/00
CPCA61K31/351A61K31/7048A61K31/7034A61K31/365A61K31/192A61P31/04A61P31/00A61K2300/00A61K31/7042A61K31/352A61P37/06A61K31/70
Inventor 于洋王建立蒋春亮王向成李玉坤李宝齐张桂萍董凯姚小青
Owner TIANJIN CHASE SUN PHARM CO LTD
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