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Artificial intervertebral disc tissue, construction method and preparation method thereof, computer readable storage medium and equipment

An intervertebral disc, artificial technology, applied in the field of intervertebral disc, can solve the problems of loss of spinal unit mobility, foreign body reaction, high price, etc., to achieve the effect of improving intervertebral disc activity, solving pain, and reducing treatment costs

Active Publication Date: 2021-07-23
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former method loses the mobility of the spinal unit, and the latter method is more expensive. At the same time, artificial intervertebral discs are mostly made of metal, and wear debris can cause foreign body reactions.

Method used

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  • Artificial intervertebral disc tissue, construction method and preparation method thereof, computer readable storage medium and equipment
  • Artificial intervertebral disc tissue, construction method and preparation method thereof, computer readable storage medium and equipment
  • Artificial intervertebral disc tissue, construction method and preparation method thereof, computer readable storage medium and equipment

Examples

Experimental program
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Effect test

preparation example Construction

[0100] The third aspect of the present invention provides the preparation method of the above-mentioned artificial intervertebral disc tissue, the preparation method comprising: constructing and obtaining the artificial intervertebral disc tissue model according to the above-mentioned construction method of the artificial intervertebral disc tissue model, and preparing the artificial intervertebral disc tissue.

[0101] In a preferred embodiment, the artificial intervertebral disc tissue is prepared by 3D printing.

[0102] According to the construction method of the above-mentioned artificial intervertebral disc tissue model, the artificial intervertebral disc tissue model is constructed and obtained, the printing path is set, the computer STL file is generated, and then the file is transferred to the program of the 3D printer to start printing.

[0103] A computer-readable storage medium, on which a computer program is stored, and when the program is executed by a processor, ...

Embodiment 1

[0107] An artificial intervertebral disc tissue comprises a first cartilage plate 1, an intervertebral disc body 2 and a second cartilage plate 3 from top to bottom, the artificial intervertebral disc tissue also includes a nucleus pulposus unit 4, and the intervertebral disc body 2 is equipped with The nucleus pulposus cavity 21 of the nucleus pulposus unit 4 and the artificial intervertebral disc tissue are cylindrical as a whole.

[0108] The first cartilage plate 1 includes 2 layers of first cartilage lamina 11, the first cartilage lamina 11 includes a plurality of parallel first cartilage units 111, the number of parallel first cartilage units is determined according to the size of the intervertebral disc, The intersection angle α of the first cartilage units 111 of the adjacent layer is 90°, and the materials of the adjacent first cartilage units are respectively polycaprolactone and hydrogel mixed with chondrocytes and chondrocyte growth factors, and the chondrocytes Th...

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Abstract

The invention provides an artificial intervertebral disc tissue, a construction method and a preparation method thereof, a computer readable storage medium and equipment. The artificial intervertebral disc tissue sequentially comprises a first cartilage plate, an intervertebral disc body part and a second cartilage plate from top to bottom, the artificial intervertebral disc tissue further comprises a nucleus pulposus unit, and the intervertebral disc body part is provided with a nucleus pulposus cavity for containing the nucleus pulposus unit. The artificial intervertebral disc tissue can effectively replace degenerated intervertebral disc tissues, improve activity of intervertebral disc, delay aging of lumbar vertebra and prolong service life of the intervertebral disc. Meanwhile, the artificial intervertebral disc tissue solves problems of intervertebral disc function loss, reduction of a motion range of a spine motion unit and intervertebral disc metal prosthesis replacement caused by lumbar intervertebral disc excision and intervertebral fusion.

Description

technical field [0001] The invention belongs to the field of intervertebral disc technology, and in particular relates to artificial intervertebral disc tissue and its construction, preparation method, computer-readable storage medium and equipment. Background technique [0002] Healthy intervertebral discs absorb and distribute shock as the vertebrae move, facilitating spinal movement. Most scholars now believe that the initiating factor of lumbar degenerative changes is the intervertebral disc, and with the increase of age, the intervertebral disc gradually degenerates, and then appears bone hyperplasia, osteophyte, ligament hypertrophy, calcification, etc. The degeneration of the intervertebral disc is the initial stage of subsequent structural degeneration Due to dynamic factors, the intervertebral disc cannot regenerate itself. [0003] At present, for the aging intervertebral discs in lumbar degenerative diseases, intervertebral disc cleaning and intervertebral bone f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/44
CPCA61F2/442
Inventor 赵杰马振江马辉王金武
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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