Traditional Chinese medicine composition for preventing and treating pulmonary arterial hypertension and application of composition

A technology of pulmonary arterial hypertension and a composition, its use in preventing and treating pulmonary arterial hypertension and its preparation, in the field of traditional Chinese medicine compositions containing Tibetan medicines, can solve problems such as unfavorable long-term treatment of pulmonary arterial hypertension, adverse reactions and the like, and achieve anti-inflammatory vascular endothelial function , Improve exercise endurance, protect the effect of vascular endothelial function

Inactive Publication Date: 2021-07-23
常州禾春医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs are all chemical drugs, all of which have various adverse reactions, which are not conducive to the long-term treatment of pulmonary hypertension.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] [Prescription] Rhododendron 1000g, pomegranate seeds 200g, safflower 10g, woody fragrance 10g

[0022] 【Preparation method】According to the above prescription, weigh the decoction pieces of the medicinal material, add distilled water 8 times the weight of the medicinal material, heat and reflux extraction, extract twice, each time for 1.5 hours, combine the filtrate, collect the volatile oil in the upper layer, add 95% ethanol to the filtrate to adjust the ethanol of the filtrate Concentration of 50%, let it stand for 12 hours, filter, combine the filtrates, recover ethanol, concentrate the filtrate to the state of liquid extract, place the obtained liquid extract in a vacuum microwave dryer to obtain dry extract, grind the obtained dry extract, add appropriate amount of Pharmaceutical excipients are directly prepared into granules by a dry method, and the volatile oil is evenly sprinkled on the surface of the granules, packaged, and prepared into granules.

Embodiment 2

[0024] [Prescription] Rhododendron 500g, pomegranate seeds 100g, safflower 100g, woody fragrance 50g.

[0025] 【Preparation method】Put the above prescription amount of medicinal materials in a high-pressure decoction machine, add appropriate amount of water, decoct for 1 hour, decoct twice, filter, combine the filtrate and let it stand, purify, and put the purified filtrate in an open container. Heat and concentrate until liquid extract (density about 1.15 g / cm3), put the extract in a vacuum dryer, dry it into a dry extract, crush and sieve the obtained dry extract, pass through a 100-mesh sieve, add appropriate amount of pharmaceutical excipients, and prepare into tablets.

Embodiment 3

[0027] [Prescription] Rhododendron 400g, pomegranate seeds 100g, safflower 80g, woody 50g.

[0028] 【Preparation method】Crush and sieve the medicinal materials of the above prescription amount respectively, pass through a 100-mesh sieve, mix evenly, and use 20% ethanol solution of povidone to make a soft material, pass through a 20-mesh sieve, extrude and granulate, and the obtained wet granules are placed in Dried in a blast drying oven at 60°C for 1.5 hours, sized the granules, added 0.4% magnesium stearate by dry granule weight, mixed evenly, filled into capsules, and prepared into capsules.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating pulmonary arterial hypertension. The traditional Chinese medicine composition is prepared from four traditional Chinese medicines including rhododendron anthopogonoide, pomegranate seeds, safflower and elecampane. The traditional Chinese medicine composition has the effects of improving exercise tolerance and reducing pulmonary arterial hypertension, and can be used for preventing and treating pulmonary arterial hypertension related diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition containing Tibetan medicine in preventing and treating pulmonary hypertension and a preparation method thereof. Background technique [0002] Pulmonary hypertension (PH) refers to a clinical and pathophysiological syndrome characterized by changes in pulmonary vascular structure or function caused by a variety of heterogeneous diseases (causes) and different pathogenesis, resulting in elevated pulmonary vascular resistance and pulmonary artery pressure. Then develop right heart failure and even death. [0003] Clinically, PH is divided into five categories: arterial PH (pulmonary arterial hypertension, PAH); PH caused by left heart disease; PH caused by lung disease and / or hypoxia; chronic thromboembolic PH (chronic thromboembolicpulmonary hypertension, CTEPH) and / or PH caused by other pulmonary artery obst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/45A61P9/12A61P29/00A61P39/00
CPCA61K36/45A61K36/185A61K36/286A61K36/285A61P9/12A61P29/00A61P39/00A61K2300/00
Inventor 张金璧范虹珏徐爱华
Owner 常州禾春医药科技有限公司
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