Mouse operation and optical imaging experiment device

Abstract

The invention relates to a mouse operation and optical imaging experiment device. The mouse operation and optical imaging experiment device comprises an operation table, a fixing part, a nose mask, an eye mask, a scalp spreader and a caudal vein injection auxiliary device, wherein the operation table is used for placing a mouse; the fixing part is used for accommodating four limbs and the tail of the mouse and realizing flexible fixation of the mouse together with the operation table; the nose mask is used for gas anesthesia of the mouse; the eye mask is used for protecting eyes of the mouse and can be used independently; the scalp spreader is used for fully exposing the brain operation view of the mouse; and the caudal vein injection auxiliary device is connected with the operation table and used for assisting puncture and injection of the caudal vein of the mouse. By means of the mouse operation and optical imaging experiment device, mouse fixation, anesthesia, caudal vein puncture administration and other experiment operations including operation and imaging can be uniformly and smoothly completed on the device, good eye protection and body temperature maintenance can be provided for the mouse, so that the experiment operations are facilitated, the experiment success rate is increased, the research range is expanded, the experiment cost is saved, and animal welfare is fully enhanced.

Description

technical field [0001] The invention relates to the field of animal experiment devices for biomedical scientific research experiments, in particular to a mouse operation and optical imaging experiment device. Background technique [0002] Mouse head surgery, such as brain drug injection or orthotopic glioma model construction, is a very important and commonly used biomedical animal experiment technique. One of the experimental instruments commonly used in the above surgical operations is a stereotaxic instrument. The instrument securely fixes the anesthetized mouse on the operating table, cuts the scalp to expose the skull, and uses a micro-injector to accurately administer drugs or tumor cells, etc. [0003] Molecular imaging technologies such as optical in vivo imaging technology and fluorescence-guided surgery have the advantages of "precise positioning" and "precise resection", with good development prospects and great potential for clinical application, so they have b...

AI Technical Summary

Problems solved by technology

However, the mouse tail vein is very small and difficult to observe. After anesthesia, the blood vessels are further constricted, so the puncture is very difficult. Once the puncture fails, repeated puncture of the mouse tail is even more difficult.

For this reason, the prior art has developed mouse tail vein special injection equipment (CN107334560A), which has improved the puncture success rate, but this type of equipment is relatively heavy, which brings inconvenience to the entire experimental operation process, and this type of equipment cannot be compared with the living body. Imager adaptation that makes real-time imaging difficult

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