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Application of trillium tschonoskii total saponins in preparation of medicine for treating arthritis

A technology of trillium and total saponins, which can be used in drug combinations, antipyretics, anti-inflammatory agents, etc., can solve problems such as unclear etiology

Inactive Publication Date: 2021-08-31
CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many inflammatory factors such as TNF-α, IL-6 and IL-1β are involved in the pathogenesis of RA, but the exact etiology is still unclear

Method used

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  • Application of trillium tschonoskii total saponins in preparation of medicine for treating arthritis
  • Application of trillium tschonoskii total saponins in preparation of medicine for treating arthritis
  • Application of trillium tschonoskii total saponins in preparation of medicine for treating arthritis

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Embodiment 1

[0021] The extraction method of trillium total saponins is to take trillium pearls and dry them in a constant temperature oven at 48°C, crush them with a traditional Chinese medicine grinder and pass them through a 60-mesh sieve, use methanol as a solvent, use a multifunctional seepage tank, normal pressure, 60°C Seepage extraction, once every 2 hours, repeated several times. The extract was concentrated under reduced pressure and freeze-dried to obtain the total trillium extract. Take an appropriate amount, add water to dissolve, extract with petroleum ether, ethyl acetate and n-butanol in sequence, concentrate under reduced pressure, and freeze-dry to obtain the n-butanol extract, which is the total saponins of Trillium. The TTM solution was prepared with carboxymethylcellulose sodium physiological saline to make the concentration 20%, sonicated for 30 minutes, and stored in a refrigerator at 4°C.

[0022] Tripterygium glycosides were purchased from Zhejiang Deende Pharmace...

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Abstract

The invention provides an application of trillium tschonoskii total saponins in preparation of a medicine for treating rheumatoid arthritis. The effect of the trillium tschonoskii total saponins on adjuvant-induced arthritis model rat inflammation is researched from an NOD-like receptor protein 3 / cysteine aspartic protease 1 pathway. The SD rats are randomly divided into a blank group, a model group, a tripterygium glycosides group, a trillium tschonoskii total saponin low-dose group, a trillium tschonoskii total saponin medium-dose group and a trillium tschonoskii total saponin high-dose group, and each group comprises six rats. The result shows that compared with the Control group, the foot swelling degree, the arthritis score, the serum TNF-alpha, IL-1beta and IL-6 levels of the AA group, the NLRP3 protein expression level in synovial tissues and the NLRP3, ASC and Caspase-1 protein levels in ankle joints are all remarkably improved; knee joint synovial cell proliferation, interstitial edema and inflammatory cell infiltration of the AA group rats; and after treatment with TG and TTM with different doses, the indexes are all improved to different degrees.

Description

technical field [0001] The invention relates to the application of trillium total saponins as a medicine for treating rheumatoid arthritis. It belongs to the field of biopharmaceuticals. Background technique [0002] Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by synovitis, clinically manifested as pain, swelling, multiple joint stiffness, fever, fatigue, and involving extra-articular organs, such as Interstitial pneumonia. After the onset, the joint destruction progresses rapidly, and once the affected joint deforms, irreversible physiological dysfunction occurs. Many inflammatory factors such as TNF-α, IL-6 and IL-1β are involved in the pathogenesis of RA, but the exact etiology is still unclear. Recent studies have shown that the mRNA expression of NOD-like receptor 3 (NLRP3) and related inflammatory factors are up-regulated in monocytes, macrophages and dendritic cells in the peripheral blood of RA patients, so the progression of rheu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P19/02A61P29/00
CPCA61K36/896A61P19/02A61P29/00A61K2236/333A61K2236/35A61K2236/51
Inventor 喻玲玲谭晓茜柳蔚李世刚史伟文蒋安蓉
Owner CHINA THREE GORGES UNIV
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