Application of fraxetin in treatment of osteoarthritis

A technology for osteoarthritis and fencetin, applied in anti-inflammatory agents, bone diseases, active ingredients of heterocyclic compounds, etc., can solve problems such as unsatisfactory effects

Pending Publication Date: 2021-10-22
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Xiaoyu San is an experienced prescription for traumatology, with good clinical curative effect, but clinically found that OA often has heat syndrome, so it is proposed to add heat-clearing drugs to improve Xiaoyu San, but the effect of traditional heat-clearing drugs is not ideal

Method used

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  • Application of fraxetin in treatment of osteoarthritis
  • Application of fraxetin in treatment of osteoarthritis
  • Application of fraxetin in treatment of osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0062] In this embodiment, the active substance afracetin was selected as an example to carry out the following experiments.

[0063] Its specific structure about fencetin is as follows:

[0064]

[0065] 1. Animal experiments

[0066] Three-month-old male SD rats (purchased from Shanghai Slack Experimental Animal Co., Ltd., weighing 180–220 g, n=18, SPF grade) were selected, and the OA rat model was established by one-knee MIA method. week;

[0067] Specific rat grouping and modeling methods:

[0068] Model group: injection of MIA into the right knee joint cavity for modeling;

[0069] Intervention group: injection of MIA into the right knee joint cavity for modeling;

[0070] Control group: injection of 50 μL of normal saline into the right knee joint cavity to simulate modeling;

[0071] Modeling method: rats were weighed and injected intraperitoneally with 10% chloral hydrate (0.3mL / 100g), and the right knee joint was shaved and disinfected with povidone iodine and...

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Abstract

The invention provides application of an active component. The active component is characterized in that the active component is selected from fraxetin or analogues or derivatives thereof; the fraxetin is a compound shown in the following structure. The active component is used for reducing the expression level of serum cartilage conversion and inflammation biomarkers of OA rats and relieving apoptosis, inflammation and matrix catabolism of cartilage cells.

Description

technical field [0001] The present invention relates to fencetin, in particular to the application of fencetin in medicines for treating, alleviating or preventing osteoarthritis. Background technique [0002] Osteoarthritis (OA) is a complex joint disease characterized by cartilage destruction. Xiaoyu San is an experienced prescription for traumatology, with good clinical curative effect, but clinically found that OA often has heat syndrome, so it is proposed to add heat-clearing drugs to improve Xiaoyu San, but the effect of traditional heat-clearing drugs is not ideal. Contents of the invention [0003] The present invention aims to overcome the above-mentioned defects, and studies the effect and mechanism of fencetin, and finds that frecetin can alleviate knee joint pain in MIA-induced OA rat model by inhibiting chondrocyte apoptosis, inflammation and extracellular matrix catabolism. cartilage destruction and inflammation. [0004] The invention provides a kind of pu...

Claims

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Application Information

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IPC IPC(8): A61K31/37A61P19/02A61P29/00
CPCA61K31/37A61P19/02A61P29/00
Inventor金立伦王庆庄迪张欣马碧涛
OwnerXIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE