Prophylactic or therapeutic agent for cancer
A therapeutic agent and colorectal cancer technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, antineoplastic drugs, etc., can solve the problems of unknown compound group cancer prevention or treatment effects, etc., to achieve inhibition of cancer cell proliferation, Improve the effect of reducing the survival rate and suppressing cancer metastasis
Pending Publication Date: 2021-10-29
TOHOKU UNIV +1
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Problems solved by technology
However, it has not been known so far that the compound group of the present application has a preventive or therapeutic effect on cancer.
Method used
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[0117] 1. Materials and methods
[0118] [Compound group of the present application]
[0119] The specific two compounds included in the compound group of the present application (compound #1 of the present application and compound #2 of the present application) are respectively based on compound #5 (equivalent to Compound #1 of the present application) and compound #35 (equivalent to compound #2 of the present application) are synthesized by the synthetic method. In the cell migration test, Compound #1 of the present application and Compound #2 of the present application were dissolved in 100% DMSO and used.
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The present invention addresses the problem of providing a low molecule compound that has an effect of preventing or treating cancer. By administering a compound represented by formula (1), a compound represented by formula (2), etc. by, for example, oral administration, cancer such as bowel cancer can be prevented or treated.
Description
technical field [0001] The present invention relates to agents for preventing or treating cancer. Background technique [0002] In the age-adjusted death rate of Japanese people classified according to the main cause of death in the "Vital Statistics" of the Ministry of Health, Labor and Welfare of Japan, malignant tumor (cancer) has been ranked first since 1981, and the death rate caused by cancer has reached the highest level in recent years. It did not show a tendency to decrease, but showed a steady or slight increase. [0003] The most common feature of cancer cells is that they exhibit rapid and uncontrollable proliferation compared to normal cells. Taking advantage of this feature, cancer chemotherapy using a drug that is toxic to proliferative cells (ie, an anticancer drug) is performed. Nucleic acid synthesis inhibitors (for example, cyclophosphamide), antibiotics (for example, actinomycin D, bleomycin), metabolic antagonists (for example, 5-fluorouracil, methotre...
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IPC IPC(8): A61P1/04A61P35/00A61P35/02A61P43/00A61K31/405
CPCA61P43/00A61K31/405A61P35/00A61P35/02A61P1/04A61K9/0053
Inventor 阿部高明大沼忍海野伦明林谦一郎
Owner TOHOKU UNIV




