Determining hematologic toxicity risk following radiotherapy

Abstract

Described is a computer-implemented method for determining a risk of hematologic toxicity in a subject to be treated with radiotherapy. The method involves processing treatment data including a prescribed dose of radiation for the subject and imaging data displaying radiation- sensitive tissues such as bone marrow and / or lymphoid organs in the subject to determine a received dose of radiation to be delivered to the radiation-sensitive tissues. The method further comprises processing patient data such as blood cell counts and the received dose of radiation to obtain a risk of hematologic toxicity in the subject in response to the radiotherapy. Also provided is a system and computer program product for performing the method.

Description

technical field [0001] Embodiments described herein relate generally to methods, systems and computer program products for determining risk of hematological toxicity. The method is particularly suitable for determining this risk of response to radiation therapy. For example, the method can be applied to determine that a subject will be at risk for acute hematological toxicity at each radiation therapy fraction. Therefore, the method can also be used to determine which patients will be at risk of blood poisoning at the end of the radiation therapy course. Background technique [0002] Rapid and severe lymphopenia (a Lymphatic reduction of blood circulation), (“Standard radiotherapy but not chemotherapy affects systemic immunity innon-small cell lung cancer”, Yazdi et al., Oncoimmunology, 2016, Volume 5, Issue 12, e1255393, “Review of hematological indices of cancer patients receiving combined chemotherapy&radiotherapy or receiving radiotherapy alone", Shahid et al, Critica...

AI Technical Summary

Problems solved by technology

Due to possible independent movement of the articulating bony anatomical components relative to each other, the sternum is not guaranteed to be in the same position as the original CT used as input for radiotherapy planning

Note that although bone misalignment can be corrected during patient setup, the correction is limited to rigid corrections (and usually only translational corrections)

Also, possibly for several treatment fractions, the positioning of the patient relative to the beam will be driven by the primary tumor location (in order to maximize tumor control), sacrificing possible additional dose to the bone marrow and other lymphoid organs (“Emerging Therapies for Stage III Non -Small Cell Lung Cancer: Stereotactic Body Radiation Therapy and Immunotherapy". Front Oncol. 2017 Sep 4 4;7:197.); thus, in current clinical practice, no consideration is given to actual absorbed dose or during or after CRT Likelihood of HT

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