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Antifungal compositions

An antifungal and composition technology, applied in the field of monoalkyl chain cationic compounds as antifungal agents, can solve problems such as limited efficacy and environmental problems

Pending Publication Date: 2021-11-16
埃克斯特大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Specifically, due to the toxicity of C12-G+ to Daphnia magna (water flea), if it is used as a fungicide for crops or soil, it may cause environmental problems because it may cause water to flow to lakes such as water bodies such as rivers
[0007] Furthermore, although C12-G+ is useful as a fungicide, it has limited efficacy when used against certain fungi

Method used

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  • Antifungal compositions
  • Antifungal compositions
  • Antifungal compositions

Examples

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Embodiment Construction

[0133] In order that the invention may be more clearly understood, embodiments thereof will now be described, by way of example only, with reference to the accompanying drawings, in which:

[0134] figure 1 is a table showing the relative efficacy of C12-G+, C18-TMA+ and C18-DMS+ in terms of antifungal activity and toxicity against two plant fungal infections (Septoria tritici and Magnaporthe oryzae on rice) ( Table 1);

[0135] figure 2 Included are 4 graphs showing the inhibitory effect of SACC C18-TMA+ and C18-DMS+ on mitochondrial potential in two phytopathogenic fungi and two human pathogenic fungi.

[0136] image 3 Includes 3 figures summarizing the results of LIVE / DEAD staining experiments evaluating C18-TMA+ in a phytopathogenic fungus that causes wheat leaf blight and two Candida species that cause infectious disease in humans and C18-DMS+ mortality.

[0137] Figure 4To show the effect of C18-DMS+ on three plants causing rice blast (Pyricularia oryzae), Septo...

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Abstract

The invention provides an antifungal composition and uses of the composition as antifungal agents. The composition comprises an antifungal compound of formula R-S+(R')2 or R-N+(R')3, wherein R is C17-C32 straight chain or branched alkyl; and each R' is independently methyl,ethyl, propyl, isopropyl or butyl.

Description

technical field [0001] The present invention relates to antifungal compositions comprising monoalkyl chain cationic antifungal compounds. The invention also relates to the use of monoalkyl chain cationic compounds as antifungal agents. In particular, the present invention relates to antifungal compositions, methods and uses. Background technique [0002] Fungi represent one of the greatest biological challenges to crop plant health and thus food security. This threat is exacerbated by intensive agricultural practices such as monoculture, where large tracts of genetically uniform varieties provide an ideal environment for the generation of new fungicide-resistant strains. In fact, fungicide resistance is emerging faster than antifungal agents are being discovered. There are only a few "new" antifungals in the "pipeline", but they are derivatives of commonly used chemicals, such as those targeting specific complexes of ergosterol biosynthesis or the mitochondrial respirator...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N31/02A01N33/12A61K31/10A61K31/14A01P3/00
CPCA01N33/12A01N31/02A61K31/14A61K31/10A61P31/10A01N25/04A01P3/00
Inventor G·斯坦伯格S·古尔M·伍德
Owner 埃克斯特大学
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