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Preparation method of compound liposome co-loaded with evodiamine and chloroquine phosphate

A technology of compound liposome and chloroquine phosphate, applied in the field of medicine, can solve the problems of low water solubility and low bioavailability, and achieve the effects of small side effects, reduced killing effect and rapid therapeutic effect.

Active Publication Date: 2021-11-26
THE AFFILIATED HOSPITAL OF GUIZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since EVO is a fat-soluble drug with low water solubility and low bioavailability in vivo, CQ also has a strong killing effect on normal tissue cells, so how to efficiently and accurately deliver EVO and CQ into tumor sites has become a key problem to be solved by the present invention

Method used

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  • Preparation method of compound liposome co-loaded with evodiamine and chloroquine phosphate
  • Preparation method of compound liposome co-loaded with evodiamine and chloroquine phosphate
  • Preparation method of compound liposome co-loaded with evodiamine and chloroquine phosphate

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Embodiment

[0024] In order to use chloroquine phosphate and evodiamine for synergistic anti-breast cancer tumors, the inventors studied how to efficiently and accurately deliver EVO and CQ into the tumor site, and try to overcome the low bioavailability of EVO in vivo and the effect of CQ on normal tissue cells. Disadvantages of strong killing effect.

[0025] The instruments used in this embodiment are as follows: SW-CJ-2F ultra-clean workbench (Antai company of Sujing Group), BB15 cell incubator (Thermo company of the United States), IX73-U inverted fluorescence microscope (Olympus company of Japan), ELX800 general Microplate reader (Bio-tek, USA), Milli-Q Elix 15Advantage ultrapure water system (Millipore, USA), RE-2000A rotary evaporator (Shanghai Yarong Biochemical Instrument Factory), 81-2 constant temperature magnetic stirrer ( Shanghai Sile Instrument Co., Ltd.), TG16W high-speed centrifuge (Changsha Xiangzhi Centrifuge Instrument Co., Ltd.), PSAC12R-120 pH meter (Dongguan Dahong...

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Abstract

The invention relates to the technical field of medicines, and discloses a preparation method of a compound liposome co-loaded with evodiamine and chloroquine phosphate, and the preparation method comprises the following steps: preparation of EVO-Lips and preparation of EVO-CQ-Lips. The invention also discloses a compound liposome and application thereof. The CQ and the EVO are jointly entrapped in the liposome to prepare the compound liposome, the compound liposome can efficiently and accurately act on breast cancer cells in vivo, the bioavailability of the EVO in vivo is improved, the killing effect of the CQ on normal tissue cells is reduced, the side effect is small, and the compound liposome can synergistically exert a lasting effect on cancer parts and synergistically kill tumor cells, and the treatment effect is quicker and more efficient.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for preparing a compound liposome co-carrying evodiamine and chloroquine phosphate. Background technique [0002] Breast cancer is the second most serious cancer that seriously endangers women's health. About 200,000 women are diagnosed with breast cancer every year in the world, and about 40,000 women die. Chemotherapy is still one of the main methods of its treatment, but the effect is not satisfactory. The reason is that there is a lack of appropriate carriers to accurately and efficiently deliver chemotherapy drugs to cancer sites to kill cancer cells. Therefore, it is of great significance to study excellent carriers to entrap chemotherapy drugs so that they can enter the cancer site as efficiently and accurately as possible and exert a lasting effect, which is of great significance to improve the therapeutic effect of chemotherapy drugs. [0003] Evodiamine (Evod...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61K9/127A61P35/00A61K31/4706
CPCA61K31/519A61K31/4706A61K9/127A61P35/00A61K2300/00Y02A50/30
Inventor 曹勇杨成莉文志鹏郑志昌李明樊兴华白洋李琳
Owner THE AFFILIATED HOSPITAL OF GUIZHOU MEDICAL UNIV
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