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Effervescent tablet with effective component being natural extract and preparation method of effervescent tablet

A technology of natural extracts and active ingredients, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and inorganic non-active ingredients, etc. High humidity requirements, inability to dissolve fully, etc.

Active Publication Date: 2021-12-10
SHENZHEN NEPTUNUS PHARMA RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] An object of the present invention is to provide a novel effervescent tablet whose active ingredient is a natural extract, so as to solve the problems of long disintegration time, inability to fully dissolve, poor effervescent form, and effective Due to the small amount of added ingredients, strong hygroscopicity of the raw and auxiliary materials of effervescent tablets, there are problems such as sticking and flushing during the production and preparation process, and high requirements for environmental humidity.

Method used

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  • Effervescent tablet with effective component being natural extract and preparation method of effervescent tablet
  • Effervescent tablet with effective component being natural extract and preparation method of effervescent tablet
  • Effervescent tablet with effective component being natural extract and preparation method of effervescent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation method of embodiment 1 effervescent tablet

[0050] 1.1 Preparation of ordinary effervescent tablets without adding zinc ion compound and uncoated

[0051] Uncoated plain effervescent tablets without added zinc ionic compound were prepared according to the following steps:

[0052] (1) Take 10% of natural extract, 13% of tartaric acid, 9.7% of citric acid, 15% of maltodextrin, and 2.5% of PEG6000 in an environment where the humidity is not higher than 40%, and mix thoroughly to obtain mixture 1;

[0053] (2) In an environment with a humidity not higher than 40%, take 30% sodium bicarbonate, 15% maltodextrin, 2.5% PEG6000, and 2% sodium chloride and mix thoroughly to obtain mixture 2;

[0054] (3) Mix mixture 1 and mixture 2, 0.1% sucralose, and 0.2% sweet orange flavor evenly in an environment where the humidity is not higher than 40%, and then press flat and obliquely punched tablets according to Ф28mm, with a hardness of 6.0-7.2kg, to obtain efferves...

Embodiment 2

[0069] Embodiment 2 does not contain the solubility of zinc ion compound and uncoated common effervescent tablet

[0070] According to the method of Example 1.1, wherein, with reference to the formula of Haiwang Jinzun chewable tablets or oral liquid, natural extract oyster powder and pueraria root extract are used as functional raw material natural extracts, mixed according to the weight ratio of 1:1, and according to The total content of the natural extracts is 20mg, 60mg, 100mg, 200mg, 400mg, respectively, and the corresponding auxiliary materials are added, and the tablet is made into 5 groups of effervescent tablets with a tablet weight of 4.0g.

[0071] Adopt the warm water of 25 ℃ of 200mL to dissolve effervescent tablet, record the dissolving time of each group of effervescent tablet, the result is as follows figure 1 shown.

[0072] The results showed that the active ingredient kudzu root extract and oyster powder were directly mixed with other excipients of the effe...

Embodiment 3

[0073] The impact of embodiment 3 zinc ion compound and coating agent on effervescent tablet

[0074] Different raw materials have different hygroscopicity. Although the use of coating agent can theoretically improve the hygroscopicity, the improvement will not be good if the dosage is too low. If the dosage is too high, it may affect the solubility of raw materials after effervescence. dissolution rate.

[0075] This example investigates the influence of zinc ion compound and coating agent on effervescent tablet.

[0076] The effervescent tablets in this example refer to the main functional ingredients in Haiwang Jinzun Tablets, and use oyster powder and Pueraria root extract, and the oyster powder and Pueraria root extract are mixed at a mass ratio of 1:1.

[0077] The effervescent tablets were divided into five groups, as shown in Table 1. According to the method of embodiment 1.1, 1.2 and 1.3 respectively, the effervescent tablet that sheet weight is 4.0g is prepared, an...

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Abstract

The invention provides a natural extract effervescent tablet and a preparation method thereof. The natural extract effervescent tablet of the invention contains a zinc ion compound and a coating agent wrapping the zinc ion compound and a natural extract, so that the common sticking phenomenon in a production process of the natural extract effervescent tablet at present is remarkably improved, the disintegration time of the effervescent tablet is shortened, the precipitation of the final effervescent solution is avoided, and on the premise of ensuring the quality of the effervescent tablet, the addition amount of the effective component, namely a naturally extracted product, is greatly increased.

Description

technical field [0001] The invention relates to an effervescent tablet whose active ingredient is a natural extract and a preparation method thereof. Background technique [0002] my country is a country with a long tradition of traditional Chinese medicine, and there is a strong demand for traditional Chinese medicine and natural or related products. A variety of traditional Chinese medicines and natural substances in daily use, including medicinal and edible substances, have various health effects, and there are many kinds of food or health products added with related ingredients on the market. There are various products on the market, including tea drinks, beverages, candies, capsules, oral liquids, chewable tablets, etc. [0003] As a relatively new type of preparation, effervescent tablets are different from conventional dosage forms in form and use compared with other preparations, and are more adaptable and acceptable to certain groups of people. At present, efferve...

Claims

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Application Information

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IPC IPC(8): A61K9/46A61K47/02A61K47/12A61K47/26A61K9/36A61K36/488A61K35/618A61K36/72A61K36/899A61K36/48
CPCA61K9/0007A61K9/2009A61K9/2013A61K9/2018A61K36/488A61K35/618A61K36/72A61K36/899A61K36/48A61K9/2866A61K2300/00
Inventor 冯贻东冯汉林黄传贵于琳王兵
Owner SHENZHEN NEPTUNUS PHARMA RES INST CO LTD
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