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A kind of auxiliary material composition, phytosterol compound nutrient chewable tablet and preparation method thereof

A technology of phytosterol and chewable tablets, which is applied in the field of preparation of phytosterol chewable tablets, and can solve problems such as sticky punches

Active Publication Date: 2021-08-27
广州莱可福生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The adjuvant composition provided by the invention can solve the problem of sticking punches in the preparation process of phytosterol tablets, and can be continuously produced for a longer period of time

Method used

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  • A kind of auxiliary material composition, phytosterol compound nutrient chewable tablet and preparation method thereof
  • A kind of auxiliary material composition, phytosterol compound nutrient chewable tablet and preparation method thereof
  • A kind of auxiliary material composition, phytosterol compound nutrient chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1: Chewable Tablets of Phytosterol Complex Nutrients for Lowering Blood Fat

[0047] Phytosterol 21%, soybean peptide powder 10.95%, maltodextrin 21%, isomalt 22%, microcrystalline cellulose 22%, fried malt powder 1%, magnesium stearate 2%, sucralose 0.05%

[0048] Obtained by following preparation steps:

[0049] 1): All raw and auxiliary materials are passed through a 60-mesh sieve.

[0050] 2): Put the sieved phytosterols, soybean peptide powder, maltodextrin, microcrystalline cellulose, isomalt, and fried malt powder in a wet granulator and mix evenly, and use water as a binder to make grain.

[0051] 3): Dry with a boiling dryer, first dry to half-dry, and then granulate with a 16-mesh sieve.

[0052] 4): The prepared semi-dry granules are then dried with a boiling dryer, the moisture content is controlled at about 4.0% to 4.5%, and then granulated with a 20-mesh sieve to control the ratio of granules to powder close to 1:1.

[0053] 5) Place the aforem...

Embodiment 2

[0055] Example 2: Chewable Tablets of Phytosterol Complex Nutrients for Lowering Blood Fat

[0056] Phytosterol 20%, soybean peptide 5%, phospholipid 5%, corn oligopeptide 4%, γ-aminobutyric acid 1.25%, natto powder 1.5%, isomalt 20%, D-mannitol 20% , Microcrystalline Cellulose 20%, Roasted Malt Powder 1.2%, Magnesium Stearate 2%, Sucralose 0.05%

[0057] 1): All raw and auxiliary materials are passed through a 60-mesh sieve.

[0058] 2): Put sieved phytosterols, soybean peptides, phospholipids, corn oligopeptides, γ-aminobutyric acid, D-mannitol, microcrystalline cellulose, isomalt, and fried malt powder in a wet Mix evenly in the French granulator, and granulate with water as the binder.

[0059] 3): Dry with a boiling dryer, first dry to half-dry, and then granulate with a 16-mesh sieve.

[0060] 4): The prepared semi-dry granules are then dried with a boiling dryer, the moisture content is controlled at about 4.0% to 4.5%, and then granulated with a 20-mesh sieve to con...

Embodiment 3

[0063] Example 3: Carrying out animal experiments on phytosterol compound nutrient chewable tablets with hypolipidemic effect

[0064] Experimental animals: Syrian golden hamster, ♂, 6-8 weeks old, body weight 90-110 g, from Beijing Weitong Lihua Experimental Animal Center, license number: SCXK (Beijing) 2012-0001. The regular feed and high-fat feed of golden hamsters were provided by Beijing Huafukang Biotechnology Co., Ltd., production license: SCXK (Beijing) 2014-0008. Conventional feed can meet all the nutritional needs of golden hamsters. Golden hamsters are raised in an SPF environment [license number SYXK (Beijing) 2013-0023], temperature (22.0±2.0) ° C, humidity 50% to 70%, 10 Rats / cage, 12h day and night, regular feed or high-fat feed, free access to water.

[0065] Reagents: Serum total cholesterol (TC) batch number 141281, triglyceride (TG) batch number 150821, low-density lipoprotein cholesterol (LDL-C) batch number 150781, all the above determination kits are fro...

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Abstract

The application relates to an auxiliary material composition, a phytosterol complex nutrient chewable tablet and a preparation method thereof. In particular, the present application relates to an auxiliary material composition for preparing chewable tablets, which comprises isomalt, microcrystalline cellulose and roasted malt in a ratio of 16-24:18-26:0.5-2.0. The present application also provides phytosterol chewable tablets containing the above-mentioned auxiliary materials and a preparation method thereof. The adjuvant composition provided by the application can reduce the occurrence of sticking during tablet preparation, and can increase the amount of phytosterol added.

Description

technical field [0001] The invention relates to an auxiliary material composition and a phytosterol chewable tablet containing the auxiliary material composition. The invention also relates to a preparation method of the phytosterol chewable tablet. Background technique [0002] The results of the 2012 National Blood Lipid Survey showed that the overall prevalence of dyslipidemia among adults in my country was as high as 40.0%. The increase in the serum cholesterol level of the population will lead to an increase of about 9.2 million people with cardiovascular diseases in my country between 2010 and 2030. The prevalence of hypercholesterolemia in children and adolescents in my country has also increased significantly, which indicates that the prevalence of dyslipidemia and related disease burden in Chinese adults will continue to increase in the future. [0003] Dyslipidemia is the primary risk factor for cardiovascular disease, among which hypercholesterolemia is an indepe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/26A61K47/38A61K47/46A61K47/12A61K47/42A61K47/24A61K47/18A61K31/575A61K38/01A61P3/06A61P9/00A23L7/20A23L29/30A23L33/11A23L33/18A23L33/115A23L33/10A23L11/00A23P10/28A23L11/50
CPCA61K9/2018A61K9/2054A61K9/2068A61K9/2013A61K47/26A61K47/38A61K47/46A61K47/12A61K9/2063A61K47/42A61K47/24A61K47/183A61K31/575A61K38/011A61K9/0056A61K9/006A61P3/06A61P9/00A23L7/20A23L29/37A23L29/30A23L33/11A23L33/18A23L33/115A23L33/10A23P10/28A23V2002/00A23L11/50A61K2300/00A23V2250/51084A23V2250/6412A23V2200/326A23V2200/3262A23V2250/038A23V2250/18A23V2250/2136A23V2250/55A23V2250/6418A23V2250/264A23V2300/10
Inventor 钟伟杰黄冬明王川易
Owner 广州莱可福生物科技有限公司
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