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Tartaric acid-nicotine salt, preparation method and application thereof, and preparation method of anhydrous tartaric acid crystal

A technology of nicotine salt and tartaric acid, applied in the field of nicotine salt, can solve problems such as poor user experience

Pending Publication Date: 2022-01-04
深圳萨特瓦生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on the market, nicotine or nicotine salts are directly added to non-combustible tobacco products such as snus, gum-based chewing tobacco, and e-cigarette liquid to solve the user's addiction to smoking. However, due to the pungent feeling of nicotine itself, It usually makes the user feel a strong spicy and throat-hitting sensation in the throat when smoking, which is not a good experience for the user

Method used

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  • Tartaric acid-nicotine salt, preparation method and application thereof, and preparation method of anhydrous tartaric acid crystal
  • Tartaric acid-nicotine salt, preparation method and application thereof, and preparation method of anhydrous tartaric acid crystal
  • Tartaric acid-nicotine salt, preparation method and application thereof, and preparation method of anhydrous tartaric acid crystal

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preparation example Construction

[0037] refer to figure 1 , one embodiment of the present invention provides a preparation method of tartrate-nicotine salt, comprising the following steps S110 and S120.

[0038] Step S110: mixing and stirring anhydrous tartaric acid crystals and propylene glycol to prepare anhydrous tartaric acid solution.

[0039] Step S120: Mixing nicotine and anhydrous tartaric acid solution.

[0040] In the preparation method of the above-mentioned tartaric acid-nicotine salt, the raw materials adopt anhydrous tartaric acid crystals, propylene glycol and nicotine, because the solubility, melting point, dissolution rate, bioavailability, etc. of the anhydrous tartaric acid crystals are different from tartaric acid with crystal water on the market, Therefore, the carboxyl group of the anhydrous tartaric acid crystal is more likely to react with the basic group to form a salt. For example, the carboxyl group of the anhydrous tartaric acid crystal is more likely to react with the nitrogen g...

Embodiment 1

[0105] The tartrate-nicotine salt of the present embodiment is prepared according to the following steps:

[0106] (1) Dissolving the crude product tartaric acid in ethanol with stirring at 40° C., and then hot filtering to obtain the filtrate;

[0107] (2) the filtrate is concentrated by rotary evaporation until crystals are separated out, and then suction filtered to obtain tartaric acid crystals;

[0108] (3) tartaric acid crystals are cleaned with ethanol, then dried to obtain anhydrous tartaric acid crystals;

[0109] (4) According to the molar ratio of anhydrous tartaric acid crystals, nicotine and propylene glycol: 1:1:4.5, prepare materials;

[0110] (5) heating and stirring anhydrous tartaric acid crystals and propylene glycol under dark conditions until dissolving, to obtain a tartaric acid solution;

[0111] (6) Stir and mix nicotine and tartaric acid solution at 40° C. to obtain tartaric acid-nicotine salt.

Embodiment 2

[0113] The tartrate-nicotine salt of the present embodiment is prepared according to the following steps:

[0114] (1) Dissolving the crude product tartaric acid in ethanol with stirring at 40° C., and then hot filtering to obtain the filtrate;

[0115] (2) the filtrate is concentrated by rotary evaporation until crystals are separated out, and then suction filtered to obtain tartaric acid crystals;

[0116] (3) tartaric acid crystals are cleaned with ethanol, then dried to obtain anhydrous tartaric acid crystals;

[0117] (4) According to the molar ratio of anhydrous tartaric acid crystals, nicotine and propylene glycol: 1.5:1:3.4;

[0118] (5) heating and stirring anhydrous tartaric acid crystals and propylene glycol under dark conditions until dissolving, to obtain a tartaric acid solution;

[0119] (6) Stir and mix nicotine and tartaric acid solution at 40° C. to obtain tartaric acid-nicotine salt.

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Abstract

The invention relates to a tartaric acid-nicotine salt, a preparation method and application thereof, and a preparation method of an anhydrous tartaric acid crystal. The preparation method of the tartaric acid-nicotine salt comprises the following steps of: mixing and stirring anhydrous tartaric acid crystals and propylene glycol to prepare an anhydrous tartaric acid solution; and mixing nicotine with the anhydrous tartaric acid solution. According to the preparation method of the tartaric acid-nicotine salt, anhydrous tartaric acid crystals, propylene glycol and nicotine are adopted as raw materials, and as the anhydrous tartaric acid crystals are different from tartaric acid with crystal water in the market in the aspects of solubility, melting point, dissolution rate, bioavailability and the like, the carboxyl of the anhydrous tartaric acid crystals is easier to generate a neutralization reaction with a basic group to generate salt, and the spicy feeling or throat striking feeling brought by nicotine to a user can be eliminated. The tartaric acid-nicotine salt prepared by the preparation method is particularly suitable for preparing non-combustion type tobacco products.

Description

technical field [0001] The invention relates to the technical field of nicotine salts, in particular to a tartaric acid-nicotine salt, a preparation method and application thereof, and a preparation method of anhydrous tartaric acid crystals. Background technique [0002] The common name of nicotine is nicotine, which is an alkaloid present in Solanaceae plants (Solanum genus). Its molecular structure consists of a pyrrole ring and a pyridine ring, so it is easy to chemically react with acid. Nicotine is also an important component of tobacco and is the main component that brings satisfaction and pleasure to tobacco product users. However, on the market, nicotine or nicotine salts are directly added to non-combustible tobacco products such as snus, gum-based chewing tobacco, and e-cigarette liquid to solve the user's addiction to smoking. However, due to the spicy feeling of nicotine itself, Usually, the user will feel a strong pungent and throat-hitting sensation in the th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D401/04C07C51/41C07C51/43C07C59/255A24B15/167A24F40/10A24F40/70
CPCC07D401/04C07C51/412C07C51/43A24B15/167A24F40/10A24F40/70C07C59/255
Inventor 谢宝林钟家鸣胡永伟
Owner 深圳萨特瓦生物科技有限公司
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