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Application of secondary metabolite of monascus fermentation product to preparation of composition for regulating blood sugar

A technology of composition and application, which is applied in the application field of secondary metabolites of red yeast rice fermentation products in the preparation of blood sugar regulating compositions, and can solve problems such as congestive heart failure, weight gain, etc.

Inactive Publication Date: 2022-01-28
SUNWAY BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, adverse drug reactions of this class of drugs include edema, weight gain, congestive heart failure, and most seriously, hepatotoxicity
[0008] From the above, it can be known that the commonly used hypoglycemic drugs have many side effects. Therefore, it is a major issue in the development of new drugs to seek novel hypoglycemic drugs without the aforementioned side effects.

Method used

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  • Application of secondary metabolite of monascus fermentation product to preparation of composition for regulating blood sugar
  • Application of secondary metabolite of monascus fermentation product to preparation of composition for regulating blood sugar
  • Application of secondary metabolite of monascus fermentation product to preparation of composition for regulating blood sugar

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0048] Preparation example 1, the preparation of red yeast rice fermentation product

[0049] (1a) wash a substrate (yam), and then use 1kg / cm 2 The pressure and the temperature of 121°C are used to perform the first disinfection procedure on the matrix;

[0050] (2a) using the substrate as a culture medium, and soaking the culture medium in a sterile distilled water;

[0051] (3a) Put Monascus purpureus into the medium, and within 48 hours, under the conditions of inoculation at a temperature of 30°C and a shaking and shaking rate of 100rpm / min~150rpm / min, complete The first inoculation of the Monascus and the culture medium;

[0052] (4a) After completing the first inoculation, take out the sterile distilled water of 100mL and the medium of 5g from the sterile distilled water;

[0053] (5a) immerse the 5 g medium with the 100 mL sterile distilled water for 7 hours;

[0054] (6a) filter the sterile distilled water with a cotton cloth, and spread the cotton cloth with 5g c...

preparation example 2

[0060] Preparation example 2, the preparation of monacin and ancaflavin

[0061] Step (1): prepare a red yeast rice fermentation product according to the method for preparation example 1;

[0062] Step (2): the red yeast rice fermentation product is repeatedly extracted three times with acetone, wherein the ratio of the red yeast fermentation product to the acetone is 1:30;

[0063] Step (3): When the product of step (2) is in the temperature range of 50° C., utilize a method of concentrating under reduced pressure to promote its concentration;

[0064] Step (4.1): adding the product obtained in step (3) into a silica gel column;

[0065] Step (4.2): Add various eluents to the silica gel column in sequence, wherein the various eluents are sequentially: hexane, hexane:ethanol=9:1 (volume ratio), hexane Alkane: ethanol=8:2, hexane: ethanol=7:3, hexane: ethanol=1:1 and ethanol;

[0066] Step (4.3): Collect the discriminating liquid flowing out from the silica gel column at reg...

Embodiment 1

[0080] Embodiment 1, preparation of composition I for regulating blood sugar of the present invention

[0081] After the powdery fermented red koji yam is obtained through step 1 (1a) to step (11a) of the above-mentioned preparation example, then the method of step (1) to step (7) of the above-mentioned preparation example 2 can be used to ferment red yeast rice from powder The pure product of monascin is obtained from yam.

[0082] Composition I for regulating blood sugar was prepared with 3 mg of monacin as an active ingredient.

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Abstract

The invention provides an application of a secondary metabolite of a monascus fermentation product in preparation of a composition for regulating blood sugar. The composition comprises an effective amount of monascin or / and ankaflavin. The invention provides another composition for regulating blood sugar. The composition comprises an effective amount of a monascus fermentation product which is prepared by inoculating monascus into a substrate and then further culturing and fermenting. The animal experiments prove that the composition for regulating blood sugar provided by the invention can effectively regulate and reduce hyperglycemia induced by high fat and high fructose diet, and also can effectively regulate and reduce oxidation pressure reaction and inflammation effect caused by hyperglycemia. Besides, the composition for regulating the blood sugar can be used for synchronously reducing AST and ALT numerical values in the liver and creatinine numerical values in the kidney while regulating and reducing the concentration of the blood sugar, so that the inflammation phenomenon of the liver and the kidney is relieved.

Description

[0001] This application is a divisional application of an invention patent application with an application date of November 13, 2015, an application number of 201510781175.5, and a title of "composition for regulating blood sugar". technical field [0002] The invention relates to the application of a secondary metabolite of a red yeast rice fermentation product in the preparation of a composition for regulating blood sugar. Background technique [0003] According to the announcement of the American Diabetes Association (ADA), when the body's fasting blood sugar is greater than 126mg / dL or the two-hour postprandial blood sugar is greater than 200mg / dL, it is diagnosed as having diabetes. In addition, for the fasting blood glucose between 100mg / dL and 126mg / dL and the two-hour postprandial blood glucose between 140mg / dL and 200mg / dL, although it does not meet the criteria for diagnosing diabetes, it is between normal and The symptoms of hyperglycemia in diabetes are called "i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K36/062A61K36/8945A61K31/365A61P3/10A61P5/50
CPCA61K36/8945A61K31/365A61K36/062A61K2300/00
Inventor 潘子明李俊霖许雅雯
Owner SUNWAY BIOTECH
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