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Compositions used for adjusting blood sugar

A technology of composition and blood sugar, which is applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc., and can solve problems such as congestive heart failure and weight gain

Inactive Publication Date: 2017-05-24
SUNWAY BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, adverse drug reactions of this class of drugs include edema, weight gain, congestive heart failure, and most seriously, hepatotoxicity
[0007] From the above, it can be known that the commonly used hypoglycemic drugs have many side effects. Therefore, finding novel hypoglycemic drugs without the aforementioned side effects has become a major issue in the development of new drugs

Method used

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  • Compositions used for adjusting blood sugar
  • Compositions used for adjusting blood sugar
  • Compositions used for adjusting blood sugar

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0047] Preparation example 1, the preparation of red yeast rice fermentation product

[0048] (1a) wash a substrate (yam), and then use 1kg / cm 2 The pressure and the temperature of 121 ℃ perform the first disinfection procedure on the matrix;

[0049] (2a) using the substrate as a culture medium, and soaking the culture medium in a sterile distilled water;

[0050] (3a) Put Monascus purpureus into the medium, and within 48 hours, under the conditions of inoculation at a temperature of 30°C and a shaking and shaking rate of 100rpm / min~150rpm / min, complete The first inoculation of the Monascus and the culture medium;

[0051] (4a) After completing the first inoculation, take out 100mL of sterile distilled water and 5g of culture medium from the sterile distilled water;

[0052] (5a) immerse the 5 g medium with the 100 mL sterile distilled water for 7 hours;

[0053] (6a) filter the sterile distilled water with a cotton cloth, and spread the cotton cloth with 5g medium on a p...

preparation example 2

[0059] Preparation example 2, the preparation of monacin and ancaflavin

[0060] Step (1): prepare a red yeast rice fermentation product according to the method for preparation example 1;

[0061] Step (2): the action of repeatedly extracting the red yeast rice fermentation product three times with acetone, wherein the ratio of the red yeast rice fermentation product to the acetone is 1:30;

[0062] Step (3): The product of step (2) is used to increase its concentration in a manner of concentration under reduced pressure when the temperature range is 50° C.;

[0063] Step (4.1): adding the product obtained in step (3) into a silica gel column;

[0064] Step (4.2): Add various eluents to the silica gel column in sequence, wherein the various eluents are sequentially: hexane, hexane:ethanol=9:1 (volume ratio), hexane Alkane:ethanol=8:2, hexane:ethanol=7:3, hexane:ethanol=1:1 and ethanol;

[0065] Step (4.3): Collect the discriminating liquid flowing out from the silica gel co...

Embodiment 1

[0079] Embodiment 1, preparation of composition I for regulating blood sugar of the present invention

[0080] After the powdery fermented red koji yam is obtained through step 1 (1a) to step (11a) of the above-mentioned preparation example, then the method of step (1) to step (7) of the above-mentioned preparation example 2 can be used to ferment red yeast rice from powder The pure product of monascin is obtained from yam.

[0081] Composition I for regulating blood sugar was prepared with 3 mg of monacin as an active ingredient.

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PUM

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Abstract

The invention provides a composition used for adjusting blood sugar. The composition comprises an effective dose of monascine or / and ankaflavin. The invention also provides another composition used for adjusting blood sugar, and the composition comprises an effective dose of a monascus fermentation product obtained via inoculation of culture medium with monascus and further fermentation and preparation. It is confirmed by animal experiments that the composition is capable of adjusting hyperglycemia caused by high fat and high sugar diet effectively, and reducing oxidative stress response and inflammation induced by hyperglycemia effectively. The composition can also be used for reducing AST and ALT values in liver and sarcosine value in kidney synchronously besides reducing of blood glucose concentration, and relieving inflammation of liver and kidney.

Description

technical field [0001] The present invention relates to a composition for regulating blood sugar. Background technique [0002] According to the announcement of the American Diabetes Association (ADA), when the body's fasting blood sugar is greater than 126mg / dL or two hours after a meal blood sugar is greater than 200mg / dL, it is diagnosed as having diabetes. In addition, for the fasting blood glucose between 100mg / dL and 126mg / dL and the two-hour postprandial blood glucose between 140mg / dL and 200mg / dL, although it does not meet the criteria for diagnosing diabetes, it is between normal and The symptoms of hyperglycemia in diabetes are called "impaired glucose tolerance (IGT), and long-term hyperglycemia will not only lead to the formation of diabetes, but also increase the risk of cardiovascular disease. [0003] Studies have pointed out that reactive oxygen species (ROS) produced by hyperglycemia (Hyperglycermia) is an important factor leading to diabetes (Diabetes mell...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K36/8945A61K36/062A61P3/10A61P5/50
CPCA61K36/8945A61K31/365A61K36/062A61K2300/00
Inventor 潘子明李俊霖许雅雯
Owner SUNWAY BIOTECH
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