Compound antihypertensive drug tablet and application thereof

A compound formula and tablet technology, applied in the field of medicine, can solve the problems of serious side effects and high cost of combined antihypertensive drugs, and achieve the effects of less side effects, reducing the occurrence of cardiovascular events, and lowering blood pressure levels.

Pending Publication Date: 2020-02-07
北京市石景山区高血压联盟研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Therefore, the problem to be solved by the present invention is to overcome the high cost of combined antihypertensive drugs in the prior art and the defects of serious side effects, thereby providing a novel compound antihypertensive drug tablet, which not only reduces the dosage of single drugs dosage, which reduces the actual number of drugs that patients take, thereby reducing drug side effects and increasing patient compliance

Method used

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  • Compound antihypertensive drug tablet and application thereof
  • Compound antihypertensive drug tablet and application thereof
  • Compound antihypertensive drug tablet and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-9

[0061] Embodiment 1-9 list is as follows:

[0062] Wherein the proportioning of main ingredients is as follows:

[0063]

[0064]Described film coating composition: the polymer coating material that comprises hydroxypropyl methylcellulose (or hydroxypropyl cellulose or polyvinyl acetate), polyethylene glycol, talcum powder, titanium dioxide and pigment , can be purchased commercially, such as OPADRYY-1-7000 produced by Shanghai Colorcon Coating Technology Co., Ltd. Suitable film coatings are known and commercially available or can be prepared according to known methods. The film coating material is typically a polymeric film coating material comprising, for example, hydroxypropylmethylcellulose, polyethylene glycol, talc and colorant materials. Generally, the film coating material is used in an amount to provide a film coating of from about 1% to about 7% by weight of the film-coated tablet.

[0065] The OPADRYY-1-7000 film coating material produced by Shanghai Kalekang ...

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PUM

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Abstract

The invention discloses a compound antihypertensive drug tablet. The compound antihypertensive drug tablet comprises the following components: amlodipine or pharmaceutically-acceptable salts thereof,amiloride or inorganic acid salts/organic acid salts of amiloride and hydrochlorothiazide or inorganic acid salts/organic acid salts thereof. The compound antihypertensive drug tablet provided by theinvention reduces the dose of a single drug and the number of drugs actually taken by a patient, thereby reducing side effects of the drugs and increasing the medicine-taking compliance of the patient.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound antihypertensive drug tablet and its application. Background technique [0002] Cardiovascular and cerebrovascular diseases have become the first cause of death among Chinese residents. Hypertension is the main factor leading to stroke, coronary heart disease, congestive heart failure and other cardiovascular diseases. A large number of domestic and foreign clinical trials have confirmed that lowering the blood pressure level of hypertensive patients can significantly reduce the incidence of cardiovascular and cerebrovascular diseases and disability rate and mortality. The latest epidemiological data show that more than 240 million adults in my country suffer from high blood pressure. How to effectively control the blood pressure of hypertensive populations to prevent stroke and cardiovascular events is a major public health problem currently facing our country [0003] At p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4422A61K31/4965A61K31/549A61P9/00A61P9/04A61P9/10A61P9/12
CPCA61K9/2054A61K9/209A61K31/4422A61K31/4965A61K31/549A61P9/00A61P9/04A61P9/10A61P9/12A61K2300/00
Inventor 胡爱华周宪梁陆培培张宇清王文刘力生
Owner 北京市石景山区高血压联盟研究所
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