Catalyst for Knoevenagel condensation reaction of aldehyde and malononitrile and preparation method thereof

Abstract

The invention discloses a catalyst for a Knoevenagel condensation reaction of aldehyde and malononitrile as well as a preparation method and application of the catalyst. The structural formula of the catalyst for the condensation reaction of aldehyde and malononitrile Knoevenagel is as shown in a formula 1, and the catalyst is synthesized by the following steps: placing cobaltous chloride, 3, 2 ', 4'-biphenyltricarboxylic acid, 4, 4 '-dipyridyl and 0.6-1.8 mmol of sodium hydroxide in water, fully stirring, transferring into a reaction kettle with a polytetrafluoroethylene lining, sealing, heating at 130-150 DEG C for 2-3 days, and cooling to room temperature to obtain the catalyst for the condensation reaction of aldehyde and malononitrile Knoevenagel. And turning off the power supply, cooling to room temperature, taking out the mixture in the kettle, washing with water, filtering, drying and separating to obtain the pink blocky crystal catalyst. The synthesis method is simple and environment-friendly, can efficiently catalyze the condensation reaction of aldehyde and malononitrile Knoevenagel in a heterogeneous manner, and has the characteristics of high activity, mild reaction conditions, low catalyst dosage, stable structure, recyclability, wide substrate application range and the like.

Description

technical field [0001] The present invention relates to a kind of catalyst and its preparation method and use, specifically the present invention is a kind of catalyst for the condensation reaction of aldehyde and malononitrile Knoevenagel, its preparation method and use. Background technique [0002] The Knoevenagel condensation reaction is a dehydration condensation reaction of carbonyl compounds and active methylene compounds. It is used for the formation of carbon-carbon double bonds and can directly synthesize a large number of useful compounds. It has a wide range of applications in many fields such as industry, agriculture, pharmaceuticals, and biological sciences. application. This type of reaction is generally carried out by using Lewis acid or alkali as a catalyst in a liquid phase, especially in an organic solvent, by heating. Ammonia, amine and its salts can also be used as a catalyst to react in a homogeneous or heterogeneous phase. , Generally, the time requir...

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Problems solved by technology

This type of reaction is generally carried out by using Lewis acid or alkali as a catalyst in a liquid phase, especially in an organic solvent, by heating. Ammonia, amine and its salts can also be used as a catalyst to react in a homogeneous or heterogeneous phase. , generally takes a long time and the yield is low[1]

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