Analgesic application of Chinese pulsatilla root or extract thereof

A Pulsatilla saponin and drug technology, applied in the field of biomedicine, can solve the problems that there is no Pulsatilla saponin B5, etc.

Active Publication Date: 2022-04-12
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The vast majority of researches reported in the previous reports focused on the many activities of Pulsatilla saponin B4. At present, there are few studies on the activity

Method used

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  • Analgesic application of Chinese pulsatilla root or extract thereof
  • Analgesic application of Chinese pulsatilla root or extract thereof
  • Analgesic application of Chinese pulsatilla root or extract thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] 1. Experimental method

[0074] 1. Construction of SNL rat model

[0075] After the rats were anesthetized, the dorsal skin was exposed by shaving. Cut the skin perpendicular to the line connecting the spine and the anterior superior iliac spine. The tissue was separated through a microscope and the transverse process of the left L6 vertebra was found to expose the L4 and L5 spinal nerves. After the L4 and L5 spinal nerves were separated, the L5 spinal nerve was ligated with surgical sutures.

[0076] 2. Experimental drugs and reagents

[0077] 2% sodium pentobarbital; Pulsatilla saponin B5; Pregabalin capsules.

[0078] 3. Grouping and administration of animals

[0079] Negative control group (Con), model group (SNL), Pulsatilla saponin B5 group (B5 for short), and pregabalin group (PGB).

[0080] There were 10 rats in each group, and the rats recovered for 3 days after modeling, and then administered continuously for 14 days, in which B5 was injected intraperito...

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Abstract

The invention provides application of pulsatilla saponin B5 or pharmaceutically acceptable salts, eutectic crystals, stereoisomers, prodrugs, solvates and metabolites thereof in preparation of drugs for preventing and/or treating pain, and the pulsatilla saponin B5 can significantly relieve the severity of neuropathic pain. For example, a mechanical pain threshold value caused by von Frey nylon fiber vertical stimulation or a crymodynia threshold value caused by acetone stimulation of a spinal nerve ligation model is improved, the effect is more excellent than that of conventionally used pregabalin, the economic burden of patients suffering from neuropathic pain and the society can be relieved, the life quality of the patients is improved, and the application prospect is wide. The method has great economic value and is suggested to be popularized and applied.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of Pulsatilla saponin B5 in the preparation of analgesic drugs. Background technique [0002] Neuropathic pain has become the top killer of chronic pain due to its long course of disease, poor curative effect, and seriously affecting the quality of life of patients. Due to its high incidence and complex pathogenesis, there is still no effective treatment for this disease. At present, drug treatment is mainly used. The commonly used first-line analgesic drug treatment includes tricyclic antidepressants (TCA), serotonin-normethyl Adrenaline reuptake inhibitors (SNRI) and gabapentin, etc., the main effect of these drugs is not analgesic, but later found to have analgesic effect, so they are listed as auxiliary analgesic drugs, and their use is beneficial to patients with kidney or Liver dysfunction, arrhythmia, mental illness, and elderly patients have many side...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K36/71A61P25/00A61K125/00
Inventor 郭秋岩赵明洪唐欢王继刚吕海宁马昂张迎夏斐史巧莉张珺哲
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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