Application of KIBRA rs17070145 detection reagent in preparation of olfactory function evaluation kit

Abstract

The invention relates to an application of a KIBRA rs17070145 detection reagent in preparation of an olfactory function evaluation kit. The olfactory function is an important reference basis for clinical disease diagnosis, and the correlation between a control brain region and a genotype of the olfactory function is researched. Researches show that the grey matter volume (GMV) of bilateral orbital frontal regions and left thalamus of a KIBRA TT carrier is obviously lower than that of a C allele carrier, and the KIBRA TT carrier can be judged as olfactory disorder. Or after correction of CC and CT genotypes and olfactory disorder is 0.687, and the olfactory function protection effect of the C allele is stronger and the olfactory disorder occurrence possibility is lower when the age is larger. Based on the achievements, the invention provides the application of the KIBRA rs17070145 detection reagent in preparation of the olfactory function evaluation kit.

Description

technical field [0001] The invention belongs to the field of olfactory function detection products, and in particular relates to the application of KIBRA rs17070145 detection reagent in the preparation of olfactory function evaluation kits. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Kidney and brain expressed protein (KIBRA) is a post-synaptic protein encoded by the WWC1 gene, which is involved in regulating the synaptic plasticity of neurons and controlling organ size by regulating cell proliferation and apoptosis. The KIBRA gene (Gene ID: 23286) is located on the long arm of chromosome 5 (5q34), and there is a common single nucleotide polymorphism (single nucleotid...

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This study showed that the GMV of the prefrontal cortex and parahippocampal cortex of KIBRA C allele carriers was significantly lower than that of TT carriers, which in turn affected the cognitive function of the elderly; Dawei Wang et al. found that compared with TT genotype individuals , C allele carriers had significantly lower GMV and increased synchronization in the right medial prefrontal cortex and bilateral dorsal anterior cingulate cortex

[0005] However, whether KIBRA rs17070145 gene polymorphism can affect olfactory function by regulating brain structure has not been reported internationally

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