Technetium-labeled specific membrane antigen developer kit as well as preparation method and application thereof
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A technetium prostate, specific technology, applied in the field of nuclear medicine, can solve the problems of high cost, difficult to popularize, etc., and achieve the effects of low use cost, simple use and mild reaction conditions
Pending Publication Date: 2022-06-03
ANHUI HUAIRENTANG PHARMA CO LTD
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[0004] Existing prostate cancer-specific nuclear medicine imaging agents are mostly 68 Ga, 18 Composed of marking with F, etc., this type of imaging agent has very strict requirements on the equipment and talents of the production and user units, and the cost is extremely high, such as cyclotrons, synthesis modules, PET / CT, etc., it is difficult to be widely popularized
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Embodiment 1
[0028] A technetium prostate marker specific membrane antigen imaging kit for 99m Tc is a radionuclide, the kit includes: 50 μg Glu-urea-Lys[(2-Nal)-X6-HYNIC], 15.42 mg ammonium acetate, 50 μg stannous chloride, 20 mg EDDA, 40 mg Tricine (three (Hydroxymethyl)methylglycine).
[0029] The preparation method of the kit is as follows: under anaerobic and sterile conditions, 50 micrograms of artificially synthesized Glu-urea-Lys[(2-Nal)-X6-HYNIC] (such as figure 1 shown), 15.42 mg (2×10 -4 mol) ammonium acetate, 50 micrograms of stannous chloride, 20 mg of EDDA, and 40 mg of Tricine, were added to 10 mL antibiotic bottles one by one, tightly sealed, and the kit was prepared.
[0030] Step-by-step single-factor changes in labeling conditions were carried out to optimize the optimal labeling conditions. Taking the most critical amount of stannous chloride (micrograms) as an example, when the amount of stannous chloride is 50 micrograms, the best, the labeling rate is about 96...
Embodiment 2
[0034] Case 1: Healthy volunteer, male, 32 years old, 99m Tc-PSMA SPECT: No discomfort, see image 3 .
Embodiment 3
[0036] Case 2: Male, 80 years old, PSA continued to rise more than 4 years after prostate cancer surgery.
[0037] see Figure 4 , the picture on the left is the conventional 18 F-FDG PET / CT examination is expensive (8000-10000 yuan / person) and can show multiple bone metastases, but the imaging quality is poor and the contrast is low; the picture on the right is 99m Tc-PSMA examination, the price is cheap, but the imaging quality is obviously better than the former, and the contrast is higher.
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Abstract
The invention discloses a technetium-labeled specific membrane antigen imaging kit which is prepared by the following steps: by taking 99mTc as radionuclide, adding 50 micrograms of artificially synthesized Glu-urea-Lys [(2-Nal)-X6-HYNIC] with the purity of more than 95%, 15.42 milligrams of ammonium acetate, 50 micrograms of stannous chloride, 20 milligrams of EDDA and 40 milligrams of Tricine into an antibiotic bottle one by one under oxygen-free and sterile conditions, and tightly sealing to complete the preparation of the kit. The invention also discloses application of the kit in preparation of a developer for specific diagnosis of prostatic cancer and application of the kit in diagnosis and treatment of prostatic cancer and myeloma. The invention is safe and effective, has no toxic or side effect, and has obvious tumor display and high contrast.
Description
technical field [0001] The invention relates to the technical field of nuclear medicine, in particular to a technetium prostate marker specific membrane antigen imaging reagent kit and a preparation method and application thereof. Background technique [0002] Prostate cancer is a malignant tumor of the urinary system with a high incidence, and its mortality rate is second only to lung cancer, and it has become one of the main lethal tumors in men. Although the incidence of prostate cancer is high, if detected early, the five-year survival rate is close to 100%, but the mortality rate of advanced prostate cancer increases sharply. At present, lesions are mainly detected by ultrasound or magnetic resonance imaging. However, these traditional imaging techniques can only observe the local situation and cannot observe the whole body, and traditional structural imaging can only be performed when the morphological structure changes significantly, and an experienced diagnosing doct...
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