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Drug-containing bamboo joint type esophageal stent

A bamboo-shaped, esophagus technology, applied in the field of medical products, which can solve problems such as inability to adjust, drug types and dose restrictions

Pending Publication Date: 2022-06-07
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs can only be loaded in the silicone rubber film. The type and dose of drugs are limited by the existing technology and production line, and cannot be adjusted in time according to the treatment needs of the disease and the characteristics of the patient.

Method used

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  • Drug-containing bamboo joint type esophageal stent
  • Drug-containing bamboo joint type esophageal stent
  • Drug-containing bamboo joint type esophageal stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1. Melatonin esophageal stent

[0033] The polyethylene glycol diacrylate 1000 is heated and melted, mixed according to the polyethylene glycol diacrylate 1000 and polyethylene glycol 400 volume ratio 3:1, add an appropriate amount of lemon yellow to dissolve, add 2,4,6-trimethylbenzoyl diphenylphosphine oxide, Merlotonine, ultrasound to dissolve, to obtain a photocuring printing solution containing Mellonine; Modeled by 3D design software, the components composed of hollow columnar structure, ring structure at both ends and umbrella-like raised structure of the outer wall are designed, in which the outer wall umbrella-like raised structure is spaced at a certain distance, and the outer wall angle between the outer wall of the umbrella-like structure and the hollow columnar structure is converted into a 3D printer that can identify the parameter file; Load the light-curing printing solution containing Mellonine into the light-curing 3D printer tank, select the param...

Embodiment 2

[0039] Example 2. Dexamethasone esophageal stent

[0040] Polyethylene glycol diacrylate 1000 heated and melted, according to the polyethylene glycol diacrylate 1000 and polyethylene glycol 400 volume ratio of 85∶15 mixed, add an appropriate amount of carmine dissolved, add 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, dexamethasone sodium phosphate injection, ultrasonic dissolution, to obtain a light-curing printing solution containing dexamethasone; Modeled by 3D design software, the components composed of hollow columnar structure, ring structure at both ends and umbrella-like raised structure of the outer wall are designed, in which the outer wall umbrella-like raised structure is spaced at a certain distance, and the outer wall angle between the outer wall of the umbrella-like structure and the hollow columnar structure is converted into a 3D printer that can identify the parameter file; Load the light-curing printing solution containing dexamethasone into the light-c...

Embodiment 3

[0041] Example 3. Ketoconazole esophageal stent

[0042]Polyethylene glycol diacrylate 1000 heated and melted, according to the polyethylene glycol diacrylate 1000 and polyethylene glycol 400 volume ratio of 75:25 mixed, add an appropriate amount of methylene blue dissolved, add 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methylpropiophenone, ketoconazole, ultrasonic dissolution, to obtain a photocuring printing solution containing ketoconazole; Modeled by 3D design software, the components composed of hollow columnar structure, ring structure at both ends and umbrella-like raised structure of the outer wall are designed, in which the outer wall umbrella-like raised structure is spaced at a certain distance, and the outer wall angle between the outer wall of the umbrella-like structure and the hollow columnar structure is converted into a 3D printer that can identify the parameter file; Load the light-curing printing solution containing ketoconazole into the light-curing 3D printer chute, s...

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PUM

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Abstract

The medicine-containing bamboo joint type esophageal stent is formed by combining a hollow columnar structure, annular structures at the two ends and outer wall umbrella-shaped protruding structures, the outer wall umbrella-shaped protruding structures are spaced by a certain distance, and a certain included angle is formed between each outer wall umbrella-shaped protruding structure and the outer wall of the hollow columnar structure. The hollow cylindrical structure can isolate the contact between the esophageal contents and the esophageal wall. The inner surface of the hollow columnar structure is smooth, so that fluid food can smoothly pass through. The medicine-containing bamboo joint type esophageal stent comprises the polymer, the pore-foaming agent and the medicine, can stay in the esophagus for a long time, releases the medicine for a long time, treats esophageal diseases and prevents the problem of esophageal stenosis caused by esophageal cell hyperplasia.

Description

Technical field [0001] The present invention relates to the field of medical products, specifically to a medicinal bamboo-type esophageal stent. Background [0002] Esophageal scaffolds are placed in the esophagus to support the walls of the esophagus, isolate moisture or food from contact with the walls of the esophagus, or play a role in propping the walls of the esophagus apart. Esophageal stents can be used for benign esophageal stenosis and malignant esophageal stenosis, and are suitable for the treatment of dilation of esophagus, cardia and anastomotic stenosis caused by a variety of etiologies, esophageal and cardia cancer with surgical contraindications, esophageal stenosis caused by chemical injury or other trauma, postoperative anastomotic stenosis after multiple dilations and tumor recurrence. Esophageal stents can be divided into two categories according to function: simple support type and therapeutic type. Simple supportive esophageal stents support the narrow segme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14A61L31/16B33Y70/10B33Y80/00A61F2/86
CPCA61L31/06A61L31/14A61L31/16B33Y70/10B33Y80/00A61F2/86A61L2300/204A61L2300/43C08L71/02
Inventor 金义光苑天宇刘冬冬魏萌袁伯川杜丽娜
Owner ACADEMY OF MILITARY MEDICAL SCI
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