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Traditional Chinese medicine composition for treating chronic benign stomach diseases and esophageal diseases

A technology of esophageal disease and composition, applied in the field of traditional Chinese medicine compositions for stomach disease and esophageal disease, can solve problems such as lack of, increase of gastric acid, etc.

Pending Publication Date: 2021-01-12
孙喜灵 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, the research and application of gastric disease drugs were mostly based on drugs that neutralize gastric acid and inhibit gastric acid secretion; relatively speaking, there has been a lack of research and use of drugs that increase gastric acid and promote gastric acid secretion.

Method used

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  • Traditional Chinese medicine composition for treating chronic benign stomach diseases and esophageal diseases
  • Traditional Chinese medicine composition for treating chronic benign stomach diseases and esophageal diseases
  • Traditional Chinese medicine composition for treating chronic benign stomach diseases and esophageal diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] This example is prepared from the following raw materials in parts by weight: 10 parts of Codonopsis pilosula, 10 parts of fried Atractylodes macrocephala, 10 parts of Poria cocos, 6 parts of bergamot, 6 parts of citron, 6 parts of Hovenia dulcis, 6 parts of Hovenia dulcis, 6 parts of seabuckthorn 6 parts, 6 parts of perilla leaves, 6 parts of dark plum, 6 parts of Daidaihua, 6 parts of ginger pinellia, and 10 parts of licorice.

[0042] Prepare the Chinese medicine composition according to the following steps:

[0043] (1), preparation medium: prepare 94g of traditional Chinese medicine composition for treating chronic benign stomach disease and esophageal disease in proportion, divide the Chinese medicine composition into four 300mL triangular flasks, and then add 33.4 mL of sterile water, 2.25 g of bran and 2.25 g of Artemisia annua;

[0044] (2) Sterilization: Put the above-mentioned triangular flask into a sterilizer, and sterilize it at 121°C and 0.12 MPa high pr...

Embodiment 2

[0053] The raw materials and proportions of this example are the same as in Example 1. When preparing the traditional Chinese medicine composition, based on Example 1, the fermentation system enlarged to 30 L is used for industrial preparation on a small scale. The steps are as follows:

[0054] (1) Preparation of culture medium: 4.32 kg of traditional Chinese medicine composition for treating chronic benign gastropathy and esophageal disease was prepared according to the same ratio as in Example 1, and then 2.6 L of sterile water, 405 g of bran and 405 g of bran were added. Artemisia annua, the prepared medium is divided into 7 aseptic feeders;

[0055] (2) Sterilization: put the above-mentioned aseptic feeder into a sterilizing pot, and sterilize for 20 minutes under the conditions of 121°C and 0.12 MPa high pressure;

[0056] (3), inoculation: put the above-mentioned sterilized traditional Chinese medicine composition into the fermentation system that has been sterilized by...

experiment example 1

[0065] Experimental example 1: Mice to promote gastrointestinal motility experiment

[0066] 1.1 Experimental method

[0067] 1.1.1 Atropine modeling experiment

[0068] 50 3-week-old male Kunming mice, weighing 18-20g. After adaptive feeding for 1 week, the mice were randomly divided into normal control group, model group (atropine group), sample high, medium and low dose groups (sample + atropine). Purified water is used as a solvent. Sample concentrated solution (equivalent to 20 g / kg crude drug, the same below), 10 g / kg (equivalent to 10 g / kg crude drug, the same below), 5 g / kg (equivalent to In crude drug 5 g / kg, the same below). Continuous gavage for 15 days. The normal control group and the model group were given the same volume of pure water by intragastric administration.

[0069] 1.1.2 L-arginine modeling experiment

[0070] 50 3-week-old male Kunming mice, weighing 18-20g. After 1 week of adaptive feeding, the mice were randomly divided into normal control g...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic benign stomach diseases and esophageal diseases. The traditional Chinese medicine composition is characterized by being prepared from the following raw medicinal materials in parts by weight: 8-12 parts of codonopsis pilosula, 8-12 parts of roasted rhizoma atractylodis macrocephalae, 8-12 parts of poria cocos,4-8 parts of fingered citron, 4-8 parts of immature bitter orange, 4-8 parts of hovenia dulcis thunb, 4-8 parts of sea-buckthorn, 4-8 parts of perilla leaves, 4-8 parts of smoked plum, 4-8 parts of seville orange flower, 4-8 parts of ginger processed pinellia and 8-12 parts of liquorice. The stomach diseases and esophageal diseases caused by insufficient secretion of gastric acid and digestive enzyme can be effectively treated by selecting targeted traditional Chinese medicine components.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating chronic benign stomach disease and esophageal disease. Background technique [0002] In recent years, the incidence of gastrointestinal diseases is on the rise due to the increase in life pressure and accelerated pace, coupled with changes in diet structure and bad eating habits, such as overeating, overeating fat, sweet and delicious, and alcoholism. According to statistics from the World Health Organization, the incidence of gastrointestinal diseases is as high as 80%, and it is increasing at a rate of about 20.0% per year. Although gastroenteropathy does not directly threaten life, it brings great pain to patients and seriously affects people's health and quality of life. If it is not treated in time, it will make the disease worse and even cause cancer, which is life-threatening. Although there are many Chine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8888A61P1/00A61P1/04
CPCA61K36/076A61K36/185A61K36/284A61K36/344A61K36/484A61K36/535A61K36/72A61K36/736A61K36/752A61K36/8888A61P1/00A61P1/04A61K2300/00
Inventor 孙喜灵张涛范庆波林剑高永林于帆林惠宇
Owner 孙喜灵
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