Near-infrared fluorescent probe taking benzylboronic acid pinacol ester as detection group as well as preparation method and application of near-infrared fluorescent probe
A technology of pinacol ester and benzyl boronic acid, applied in the field of anion detection, can solve the problems of short fluorescence emission wavelength, high detection limit, low sensitivity, etc., achieve specific detection, large tissue penetration, and reduce autofluorescence Effect
Pending Publication Date: 2022-06-21
NORTHWESTERN POLYTECHNICAL UNIV
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Problems solved by technology
[0005] The purpose of the present invention is to solve the shortcomings of low sensitivity, high detection limit, poor water solubility and short fluorescence emission wavelength in existing ONOO-detection probes, and provide a kind of benzylboronic acid pinacol ester Near-infrared fluorescent probe as a detection group and its preparation method and application
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[0034] The content of the present invention is described in further detail below in conjunction with the accompanying drawings and specific embodiments:
[0035] ONOO designed by the present invention - The specific synthesis process and characterization of the near-infrared fluorescent probe are as follows:
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The invention provides a near-infrared fluorescent probe taking benzylboronic acid pinacol ester as a detection group as well as a preparation method and application of the near-infrared fluorescent probe, aiming at overcoming the defects that most of existing nitrosyl peroxide anion detection probes are low in sensitivity, high in detection limit, relatively poor in water solubility and relatively short in fluorescence emission wavelength. The near-infrared fluorescent probe designed by the invention is relatively low in light scattering level, autofluorescence of biological cells can be reduced, larger tissue penetration can be realized, and rapid, sensitive, efficient and specific detection of the nitrosyl peroxide anions can be realized through a fluorescence emission spectrum.
Description
technical field [0001] The invention belongs to the technical field of anion detection, and in particular relates to a near-infrared fluorescent probe using benzylboronic acid pinacol esters as a detection group and a preparation method and application thereof. Background technique [0002] Nitrosyl peroxide anion (ONOO - ) was discovered and confirmed by Beckman and other scientists more than 30 years ago by O 2 ·- Anions with strong oxidizing, nucleophilic and nitrifying characteristics produced by rapid combination with NO play a very important role in signal transduction and antibacterial processes; on the other hand, excessive ONOO - It also interacts with many important biomolecules, such as lipids, DNA and proteins, to cause damage to the organism, and is associated with many diseases such as neurodegenerative diseases, cardiovascular diseases, inflammation and cancer. Therefore, the development of high-sensitivity, high-selectivity, and in-situ online detection of...
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IPC IPC(8): C07F5/02C09K11/06G01N21/64
CPCC07F5/02C09K11/06G01N21/643C09K2211/1096C09K2211/1029C09K2211/1011
Inventor 程帅词孙然
Owner NORTHWESTERN POLYTECHNICAL UNIV
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