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New use of sulpiride in pharmacy

A technology of dioxymethamphetamine and neurotoxicity is applied in the field of pharmacy to achieve obvious social and economic benefits, and the effects of resisting harm

Inactive Publication Date: 2005-10-05
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

At present, the main treatment and intervention directions focus on using drugs to induce hypothermia or prevent MDMA-induced hyperthermia, but there is no drug that can effectively antagonize this type of neurotoxicity

Method used

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  • New use of sulpiride in pharmacy
  • New use of sulpiride in pharmacy
  • New use of sulpiride in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] 1. Materials and methods

[0016] 1.1 Materials

[0017] 1.1.1 Animals 150 male Wistar rats, weighing 140±2 grams, were purchased from the Experimental Animal Center of Sichuan University. The animals were randomly divided into 10 groups, 15 in each group. Before the experiment, the animals were allowed to adapt to a clean constant temperature (20°C ± 2°C) constant humidity (humidity 50%) breeding room for 3 days, grabbed once a day, and raised in a single cage. During the whole experiment, they were allowed to drink water and eat freely.

[0018] 1.1.2 Drugs and reagents MDMA is provided by the China Institute for the Control of Pharmaceutical and Biological Products. Sulpiride was provided by Shanghai Hefeng Pharmaceutical Factory (batch number 000801). All the above medicines were dissolved in normal saline, and the administration volume was 1ml / kg. SERTmRNA in situ hybridization kit was purchased from Wuhan Boster Company. 10% chloral hydrate (provided by the Ph...

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Abstract

The invention discloses the application of sulpiride in medicine for treating or preventing neurotoxicity caused by 3,4 methylenedioxymethamphetamine (MDMA). Giving sulpiride half an hour before giving MDMA to the experimental rats, giving sulpiride while giving MDMA to the experimental rats, giving sulpiride half an hour, 5 hours, and 12 hours after giving MDMA to the experimental rats, all can reduce the frontal lobe cortex. The depletion of 5-HT in the three brain regions of brain, hippocampus and striatum has obvious inhibitory effect on the down-regulation of SERTmRNA expression; the results of neuropathology show that sulpiride can also inhibit the reduction of silver-stained positive area caused by MDMA, and inhibit the expression of SERT mRNA. Down-regulate the expression of glial fibrillary acidic protein (GFAP), which indirectly reflects the reduction of nerve damage. The dose of sulpiride given is 40mg / kg-80mg / kg.

Description

technical field [0001] The present invention relates to the use of the antipsychotic drug sulpiride, especially the use in the field of pharmacy. Background technique [0002] 3,4-methylenedioxy-methamphetamine (3,4-methylenedioxy-methamphetamine, MDMA, commonly known as "ecstasy" in my country, in the follow-up content of this manual, "MDMA" stands for "3,4-methylenedioxymethyl Amphetamine") belongs to the amphetamine-type stimulants and is also a powerful indirect monoaminergic agonist that can induce novelty, enhance pleasure, and increase excitability. It is an illegal drug that is easily obtained in entertainment venues (Kaplan HI, and Sadock BJ. Synopsis of Psychiatry. 8th ed. Baltimore: Maryland Composition publishers, Inc. 1998, pp: 407-412). In recent years, amphetamine-type stimulants represented by MDMA have spread rapidly internationally, and our country is also facing the threat of MDMA epidemic abuse after heroin. MDMA can destroy the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/40A61P25/00A61P25/36
Inventor 王雪黄明生孙学礼李静李素霞况伟宏
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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