3,4'-5-trihydroxystlbenes compounds with functions of reducing pulmonary artery high pressure and improving respiration function

Abstract

A 3',4',5-trihydroxystlbene compound for lowering the high tension of arteria pulmonalis and improving respiratory function is disclosed. It includes polydatin (or piceid) and resveratnol prepared by hydrolyzing polydatin.

Description

[0001] 1. Field [0002] The present invention belongs to the category of medicine (A61p11 / ), relates to a polydatin compound, in particular to a polydatin compound (polydatin, a compound with a stilbene triphenol structure) for reducing pulmonary hypertension and improving respiratory function ). 2. Background technology [0003] In recent years, due to environmental pollution and other reasons, the incidence and harmfulness of cor pulmonale have become increasingly serious, making the development of drugs that can effectively regulate pulmonary arterial pressure (hph) and prevent and treat cor pulmonale more important. At present, there are many related reports at home and abroad. Vasodilator drugs are the most researched drug therapy, but the clinical effect of existing therapeutic drugs is not satisfactory, this is because: (1) most of the existing drugs for lowering pulmonary arterial pressure (except inhaled NO) are for the treatment of hypertension The drug lacks speci...

AI Technical Summary

Problems solved by technology

Vasodilator drugs are the most researched drug therapy, but the clinical effect of existing therapeutic drugs is not satisfactory, this is because: (1) most of the existing drugs for lowering pulmonary arterial pressure (except NO inhalation) are used to treat hypertension Drugs, lacking specificity to pulmonary vessels, reduce pulmonary arterial pressure while also reducing systemic blood pressure, causing hypotensive reactions

(2) Most drugs that reduce pulmonary arterial pressure have a greater impact on the ventilation/blood flow ratio. While reducing blood pressure, the PaO will be lowered due to no improvement in ventilation. 2 Reduce and aggravate hypoxia, which is not good for the treatment of c