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Application of kaempferol and its derivative in preparing medicine for cardiac and cerebral vascular diseases

A technology of kaempferol and derivatives, which can be applied in the field of medicine and can solve unseen and other problems

Inactive Publication Date: 2003-03-19
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The flowers or leaves of safflower, breviscapus, and ginkgo have been used to prevent and treat cardiovascular and cerebrovascular diseases, but there is no report about the preparation of drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases on the kaempferol and its derivatives contained in them.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach ： Embodiment 1

[0015] The specific embodiment: embodiment 1: prepare kaempferol; 6-hydroxy kaempferol; kaempferol-3-glucoside; kaempferol-3-rutinoside; 6-hydroxy kaempferol-3-glucoside; 6-hydroxy kaempferol -3,6-diglucoside; 6-hydroxykaempferol-3,6,7-triglucoside;

[0016] Take 30kg of Hefei safflower dried medicinal materials, soak them in 100L of 80% ethanol at room temperature for 48 hours, extract three times, combine the extracts, recover ethanol under reduced pressure, and obtain a concentrated solution; extract with petroleum ether, diethyl ether, and water-saturated n-butanol sequentially , Discard the petroleum ether extract, concentrate the diethyl ether and n-butanol extracts under reduced pressure, respectively, and perform column chromatography one by one.

[0017] 1. The ether extract was subjected to silica gel column chromatography, and eluted with petroleum ether-ethyl acetate (30:1-1:1) and chloroform-methanol (10:1-1:1, the same below) solvent system as usual , collect th...

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Abstract

The present invention relates to the field of medicine technology. Safflower, crigeron bieriscapus, ginkgo leaf and other plant flower and leaf containing kaempferol and its derivative, rather than kaempferol and its derivative, have been used in preventing and treating cardiac and cerebral vascular diseases. The present invention verifies that kaempferol and its derivative has the functions of preventing and treating cardiac and cerebral vascular diseass via systemic pharmacological and pharmacodynamical experiments. Therefore, kaempferol and its derivative may be used in preparing medicine for preventing and treating cardiac and cerebral vascular diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to the application of kaempferol and derivatives thereof in the preparation of drugs for preventing and treating cardiovascular and cerebrovascular diseases. Background technique [0002] Safflower (Flos Carthami) is a commonly used traditional Chinese medicine, which has the effects of promoting blood circulation, promoting menstrual flow, dispelling blood stasis and relieving pain. It has been used clinically to prevent and treat cardiovascular and cerebrovascular diseases. Paralysis caused by cerebrovascular accidents such as hypertension, cerebral thrombosis, cerebral hemorrhage, polyneuritis, chronic arachnoiditis, coronary heart disease, angina pectoris and other diseases; Ginkgo biloba has been made into ginkgo biloba capsules and other dosage forms for cardiovascular and cerebrovascular diseases Disease prevention and treatment. Analyzing their chemical composition, they all...

Claims

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Application Information

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IPC IPC(8): A61K31/325A61K31/352A61P9/10
Inventor 郭美丽张戈
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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