Medicinal polysaccharide component of spinulate hedgehog fungus, its prepn and medicinal composition

A technology of Hericium erinaceus and polysaccharides, which can be used in drug combinations, organic active ingredients, and pharmaceutical formulas, and can solve problems such as unclear active substance ingredients, inconvenient application for diabetics, and limitations in therapeutic applications.

Inactive Publication Date: 2003-11-05
吉林省生物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because it is not extracted, it contains a variety of culture medium components, the effective ingredients are not clear, the quality standard of the drug is not well controllabl

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Weigh 1Kg of the fruiting body of Hericium erinaceus, add 20Kg of water, and extract 3 times at 95°C for 1 hour each time. The extracts were combined, filtered, concentrated in vacuo under reduced pressure, and the thermal specific gravity was 1.04, and finely filtered. Add edible ethanol to precipitate, and the final concentration reaches 70%. Filter to collect the precipitate and dissolve in water. Centrifuge to remove slag, take the supernatant alcohol precipitation (alcohol concentration 70%) 2-3 times, and collect the precipitate-polysaccharide (HP) 70g.

Embodiment 2

[0072] Weigh 1Kg of Hericium erinaceus mycelium, add 20Kg of water, and extract at 98°C for 3 times, each time for 1 hour. The extracts were combined, filtered, concentrated in vacuo under reduced pressure, and the thermal specific gravity was 1.04, and finely filtered. Add edible ethanol to precipitate, and the final concentration reaches 80%. Filter to collect the precipitate and dissolve in water. Centrifuge to remove slag, take the supernatant alcohol precipitation (alcohol concentration 80%) 2-3 times, and collect 50 g of the precipitate—polysaccharide (HP).

Embodiment 3

[0074] Weigh 1Kg of the fruiting body of Hericium erinaceus, add 20Kg of water, and extract 3 times at 96°C for 1 hour each time. The extracts were combined, filtered, concentrated under reduced pressure and in vacuo, the thermal specific gravity was 1.06, and finely filtered. Add 2g of enzyme, adjust temperature to 35-60°C, pH value to 5-7, and hydrolyze protein. Finely filter, add edible ethanol to precipitate, and the final concentration reaches 60%. Filter, collect the precipitate, dissolve it in water, and repeat the alcohol precipitation 2-3 times, and collect the precipitate—polysaccharide (HP) 70g.

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Abstract

Spinulate hedgehog fungus with sporophore used as material is processed through water decoction for 1-3 times, filtering with filtrate being merged, concentration, addition of enzyme, regulating of temperature and pH value, elimination of protein, straining, alcohol precipitation, filtering to collect precipitate, water dissolving, centrifugation to eliminate dregs, and alcohol precipitation of supernatant to collect spinulate hedgehog fungus polysaccharide. Medicine with spinulate hedgehog fungus polysaccharide as main medicinal component is provided and the medicine may be used in treating chronic atrophic gastritis, superficial gastritis, peptic gastric ulcer, duodenal ampulla ulcer and other gastric diseases and has pain relieving and antiinflammation functions.

Description

Technical field: [0001] The invention discloses a medicinal ingredient of Hericium erinaceus polysaccharide, and provides a preparation method thereof and a pharmaceutical composition using the compound as an active ingredient, and belongs to the technical field of extraction and application of active ingredients of traditional Chinese medicines. Background technique: [0002] Hericium Caput-medusae (Bull.ex Fr) Pers of the present invention is the same bacterial strain as the drug "Weilexin" for treating gastric ulcer and chronic atrophic gastritis. "Weilexin" is produced by deep-fermenting Hericium erinaceus and then concentrating the fermented liquid. Because it is not extracted, it contains a variety of culture medium components, the effective ingredients are not clear, the quality standard of the drug is not well controllable, and the drug also contains a lot of sugar, which brings a lot of inconvenience to the application of diabetic patients. Its therapeutic applicati...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/04C08B37/00
Inventor 张金亭周东亚黄勇李敬轩李金花于文斌赵丽茹
Owner 吉林省生物研究所
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