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Mesilate phentolamine suppository and its preparation

A technique for vaginal administration of phentolamine mesylate, applied in suppository delivery, diseases, drug combinations, etc., can solve the problems of unsatisfactory ED patients and female frigidity patients, fewer dosage forms, fewer varieties, etc., and achieve Improve sexual function, improve sexual function, and facilitate absorption

Inactive Publication Date: 2003-11-19
武汉同药物业管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of medicine has the problems of few varieties and few dosage forms, which is far from meeting the needs of ED patients and female frigidity patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1: Preparation method of phentolamine mesylate suppository based on semi-synthetic fatty acid glyceride. Take 1140g of semi-synthetic fatty acid glyceride, heat and melt at about 50-70℃, add 600g of phentolamine mesylate that has passed 80-100 mesh sieve, stir well, pour into PVC / PE suppository, cool, Get it in the package. Each capsule contains 60mg of tolamine mesylate, making a total of 1000 capsules, each weighing 1.2g.

Embodiment 2

[0058] Example 2: Preparation method of phentolamine mesylate suppository based on semi-synthetic fatty acid glyceride. Take 1140g of semi-synthetic fatty acid glycerides, heat and melt at about 50-70℃, transfer to the colloid mill while it is hot, add 60g of phentolamine mesylate, and grind it into a uniform slurry. Finally, pour into PVC / PE capsule, cool and pack it. Each capsule contains 60mg of tolamine mesylate, making a total of 1000 capsules, each weighing 1.2g.

Embodiment 3

[0059]Example 3: Preparation method of phentolamine mesylate suppository based on cocoa butter. Take 1120g of cocoa butter, heat it to melt at about 50-70℃, transfer to the colloid mill while it is hot, turn on the colloid mill, slowly add 80g of phentolamine mesylate, grind for a suitable time, pour into PVC / PE plug Get it in the bag, cool and pack. Each capsule contains 80 mg of phenoxyamine mesylate, making a total of 1000 capsules, each weighing 1.2 g.

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PUM

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Abstract

A phentolamine mesylate in the form of suppository for treating male sexual disfunction and female asexuality by applying it via rectum or vagina is disclosed. Its advantages are high curative effect and low toxic by-effect.

Description

Technical field [0001] The present invention relates to a new preparation of synthetic drug phentolamine mesylate, in particular to a phentolamine mesylate suppository that is administered by rectum or vagina for the treatment of male sexual dysfunction (ED) and female frigidity And its preparation method. The suppository includes phentolamine mesylate and a base, wherein the content of phentolamine mesylate per suppository is 40-80 mg. Background technique [0002] There are more than 100 million male patients with sexual dysfunction in my country, and the statutory drugs approved by the State Food and Drug Administration are only in two dosage forms: tablets and capsules, and the only varieties are the imported drug cedilafil (Viagra) and the domestic drug methanesulfonate Phentolamine acid dispersible tablets and capsules. This kind of medicine has the problem of fewer varieties and fewer dosage forms, which is far from meeting the needs of ED patients and female patients with...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K31/417A61P15/08A61P15/10
Inventor 韩昌志
Owner 武汉同药物业管理有限公司
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