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Use of muskmelon plant extract in pharmacy

A kind of plant extract and extract technology, applied in seedlings, melon pedicles, roots, and stem extracts in the field of pharmaceuticals, can solve the problems of unreported research on the treatment of hepatitis, and achieve definite curative effect

Inactive Publication Date: 2004-08-18
杨世杰 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few studies on the chemical composition and pharmacological effects of melon pedicles at home and abroad, and there are no reports on the research on the treatment of hepatitis with melon pedicles, seedlings, roots and stems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 plant extract

[0020] ①Take 15 kg of melon plants, reflux extraction with 8 times the amount of 75% ethanol twice, each time reflux extraction for 1 hour, filter, combine the filtrate, recover the ethanol as much as possible, and concentrate to a relative density of 1.02-1.08, let stand, filter, high-speed Centrifuge, adjust the pH to 2-3 with dilute hydrochloric acid, extract with ethyl acetate 6 times the volume of the concentrated solution, combine the extracts, recover the ethyl acetate to obtain the melon pedicle extract. ②The melon plant extract is dried under reduced pressure, pulverized, and passed through an 80-mesh sieve to obtain the plant extract of the present invention.

Embodiment 2

[0021] The preparation of embodiment 2 plant extract powder injection

[0022] Embodiment 1 Melon plant extract 15 grams

[0023] Mannitol 20g

[0024] Take the plant extract of Example 1, put it in a suitable container, add about 900ml of water for injection, add mannitol and stir evenly, then add water for injection to 1000ml, filter it with a 0.22um microporous membrane, and fill it under sterile conditions In vials, partly plugged with butyl rubber stoppers, packed into plates, and freeze-dried. After the freeze-drying is finished, stoppering and capping are ready.

Embodiment 3

[0025] The preparation of embodiment 3 plant extract injection liquid

[0026] Embodiment 1 plant extract 15g

[0027] Tween-80 1ml

[0028] Add water for injection to 1000mt

[0029] Take the plant extract of Example 1, dissolve it with 900ml of water for injection, then adjust the pH to 6-7 with 1% sodium hydroxide solution, add 1ml of Tween-80, add water for injection to 1000ml, let it stand, and use 0.22um The preparation is obtained by filtering with a microporous membrane, potting, and sterilizing by flowing steam.

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Abstract

The present invention relates to the application of sweet melon extractive in preparing medicine, and belongs to the field of pharmaceutical technology. The sweet melon extractive contains the active component melon stem essence in 0.1-5.0 %, and is used in treating hepatitis. It has the effects of resisting hepatitis virus, protecting liver and lowering aminotransierase and has determined curative effect and no toxic side effect.

Description

Technical field: [0001] The present invention relates to the use of the melon plant extract, in particular to the use of the pedicle, seedling, root and stem part extract of the melon in the field of pharmacy. Background technique: [0002] Hepatitis B is a worldwide infectious disease caused by Hepatitis B Virus (BBV). According to statistics, the number of people carrying hepatitis B surface antigen (HBsAs) in the world exceeds 320 million. China is a high-endemic area of ​​hepatitis B. 40% to 60% of the population has been infected by HBV, and 10% of the population (about 130 million people) ) is a chronic HBsAg carrier. According to the survey, there are more than 40 million patients suffering from chronic hepatitis B in China, and more than 25% to 40% of them develop liver cirrhosis or liver cancer. There are 500,000 people who die of liver cirrhosis after hepatitis B in China every year. People who are chronically infected by HBV The relative risk of developing prima...

Claims

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Application Information

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IPC IPC(8): A61P1/16A61P31/12
Inventor 杨世杰昌友权李红
Owner 杨世杰
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